Outbreak of CTX-M-15-producing Klebsiella pneumoniae of sequence type 199 in a Latvian teaching hospital

Uga Dumpis, Aina Iversen, Arta Balode, Mara Saule, Edvins Miklaševičs, Christian G. Giske

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Previous studies on the epidemiology of extended-spectrum -lactamase (ESBL)-producing Enterobacteriaceae in Latvia are lacking. ESBL-producing Klebsiella pneumoniae (n = 32) were subjected to pulsed-field gel electrophoresis (PFGE) and selected isolates to multi-locus sequence typing (MLST). Species identification and susceptibility testing were performed using VITEK2, and sequencing of blaCTX-M was performed in selected isolates. PFGE revealed one major clone (n = 23), with most of the isolates derived from the ICU. The clone harboured blaCTX-M-15, was sequence type 199 and comprised two ertapenem non-susceptible isolates. This is the first report of an ESBL outbreak in Latvia, and calls for increased epidemiological typing of ESBL-producing Enterobacteriaceae, as well as improved infection control routines.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalAPMIS
Volume118
Issue number9
DOIs
Publication statusPublished - Sep 2010

Keywords

  • clonal complex
  • CTX-M
  • ESBL
  • MLST
  • ST

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'Outbreak of CTX-M-15-producing Klebsiella pneumoniae of sequence type 199 in a Latvian teaching hospital'. Together they form a unique fingerprint.

Cite this