Overexpression of MRPS18-2 in cancer cell lines results in appearance of multinucleated cells

Z. Shevchuk; M. Y. Yurchenko; S. D. Darekar; I. Holodnuka-Kholodnyuk; V. I. Kashuba; E. V. Kashuba

doi:10.32607/20758251-2013-5-1-85-89

Overexpression of MRPS18-2 in cancer cell lines results in appearance of multinucleated cells

Z. Shevchuk, M. Y. Yurchenko, S. D. Darekar, I. Holodnuka-Kholodnyuk, V. I. Kashuba, E. V. Kashuba

Institute of Microbiology and Virology

Research output: Contribution to journal › Article › peer-review

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Abstract

Human mitochondrial ribosomal protein MRPS18-2 (S18-2) is encoded by a cellular gene that is located on the human chromosome 6p21.3. We discovered that overexpression of the S18-2 protein led to immortalization and de-differentiation of primary rat embryonic fibroblasts. Cells showed anchorage-independent growth pattern. Moreover, pathways characteristic for rapidly proliferating cells were upregulated then. It is possible that the S18-2 overexpression induced disturbance in cell cycle regulation. We found that overexpression of S18-2 protein in human cancer cell lines led to an appearance of multinucleated cells in the selected clones.

Original language	English
Pages (from-to)	85-89
Number of pages	5
Journal	Acta Naturae
Volume	5
Issue number	16
DOIs	https://doi.org/10.32607/20758251-2013-5-1-85-89
Publication status	Published - 2013

Keywords*

Cancer cell line
Cell cycle
Mitochondrial ribosomal protein S18-2 (MRPS18-2)
Multinucleated cells
RB binding protein

Field of Science*

1.6 Biological sciences
3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.32607/20758251-2013-5-1-85-89

Overexpression of MRPS18-2 in Cancer CellFinal published version, 9.95 MBLicence: CC BY

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title = "Overexpression of MRPS18-2 in cancer cell lines results in appearance of multinucleated cells",

abstract = "Human mitochondrial ribosomal protein MRPS18-2 (S18-2) is encoded by a cellular gene that is located on the human chromosome 6p21.3. We discovered that overexpression of the S18-2 protein led to immortalization and de-differentiation of primary rat embryonic fibroblasts. Cells showed anchorage-independent growth pattern. Moreover, pathways characteristic for rapidly proliferating cells were upregulated then. It is possible that the S18-2 overexpression induced disturbance in cell cycle regulation. We found that overexpression of S18-2 protein in human cancer cell lines led to an appearance of multinucleated cells in the selected clones.",

keywords = "Cancer cell line, Cell cycle, Mitochondrial ribosomal protein S18-2 (MRPS18-2), Multinucleated cells, RB binding protein",

author = "Z. Shevchuk and Yurchenko, {M. Y.} and Darekar, {S. D.} and I. Holodnuka-Kholodnyuk and Kashuba, {V. I.} and Kashuba, {E. V.}",

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doi = "10.32607/20758251-2013-5-1-85-89",

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TY - JOUR

T1 - Overexpression of MRPS18-2 in cancer cell lines results in appearance of multinucleated cells

AU - Shevchuk, Z.

AU - Yurchenko, M. Y.

AU - Darekar, S. D.

AU - Holodnuka-Kholodnyuk, I.

AU - Kashuba, V. I.

AU - Kashuba, E. V.

PY - 2013

Y1 - 2013

N2 - Human mitochondrial ribosomal protein MRPS18-2 (S18-2) is encoded by a cellular gene that is located on the human chromosome 6p21.3. We discovered that overexpression of the S18-2 protein led to immortalization and de-differentiation of primary rat embryonic fibroblasts. Cells showed anchorage-independent growth pattern. Moreover, pathways characteristic for rapidly proliferating cells were upregulated then. It is possible that the S18-2 overexpression induced disturbance in cell cycle regulation. We found that overexpression of S18-2 protein in human cancer cell lines led to an appearance of multinucleated cells in the selected clones.

AB - Human mitochondrial ribosomal protein MRPS18-2 (S18-2) is encoded by a cellular gene that is located on the human chromosome 6p21.3. We discovered that overexpression of the S18-2 protein led to immortalization and de-differentiation of primary rat embryonic fibroblasts. Cells showed anchorage-independent growth pattern. Moreover, pathways characteristic for rapidly proliferating cells were upregulated then. It is possible that the S18-2 overexpression induced disturbance in cell cycle regulation. We found that overexpression of S18-2 protein in human cancer cell lines led to an appearance of multinucleated cells in the selected clones.

KW - Cancer cell line

KW - Cell cycle

KW - Mitochondrial ribosomal protein S18-2 (MRPS18-2)

KW - Multinucleated cells

KW - RB binding protein

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DO - 10.32607/20758251-2013-5-1-85-89

M3 - Article

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SN - 2075-8251

VL - 5

SP - 85

EP - 89

JO - Acta Naturae

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ER -

Overexpression of MRPS18-2 in cancer cell lines results in appearance of multinucleated cells

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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