Overlaps in the Pathogenesis of Rosacea and Atherosclerosis

Aleksejs Zavorins; Julija Voicehovska; Janis Ķisis; Aivars Lejnieks

doi:10.2478/prolas-2018-0006

Overlaps in the Pathogenesis of Rosacea and Atherosclerosis

Aleksejs Zavorins, Julija Voicehovska, Janis Ķisis, Aivars Lejnieks

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Abstract

Rosacea is a chronic inflammatory skin disease characterised by transient or persistent erythema, telangiectasia, papules, and pustules that predominantly involve central regions of the face. Recent studies have shown a possible clinical association between rosacea and cardiovascular diseases (CVDs). Rosacea and atherosclerosis are both known to have alterations in the innate immune system, enhanced oxidative and endoplasmic reticulum stress. The aim of this review is to delve deep into the pathogenesis of rosacea and atherosclerosis to uncover possible pathogenic overlaps between these chronic inflammatory diseases.

Original language	English
Pages (from-to)	152-159
Number of pages	8
Journal	Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume	72
Issue number	3
DOIs	https://doi.org/10.2478/prolas-2018-0006
Publication status	Published - 1 Jun 2018

Keywords*

atherosclerosis
endoplasmic reticulum stress
LL-37
oxidative stress
rosacea
Toll-like receptor 2

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2478/prolas-2018-0006Licence: CC BY-NC-ND

Overlaps in the pathogenesis of rosaceaFinal published version, 101 KBLicence: CC BY-NC-ND

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title = "Overlaps in the Pathogenesis of Rosacea and Atherosclerosis",

abstract = "Rosacea is a chronic inflammatory skin disease characterised by transient or persistent erythema, telangiectasia, papules, and pustules that predominantly involve central regions of the face. Recent studies have shown a possible clinical association between rosacea and cardiovascular diseases (CVDs). Rosacea and atherosclerosis are both known to have alterations in the innate immune system, enhanced oxidative and endoplasmic reticulum stress. The aim of this review is to delve deep into the pathogenesis of rosacea and atherosclerosis to uncover possible pathogenic overlaps between these chronic inflammatory diseases.",

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author = "Aleksejs Zavorins and Julija Voicehovska and Janis Ķisis and Aivars Lejnieks",

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doi = "10.2478/prolas-2018-0006",

language = "English",

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journal = "Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences",

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T1 - Overlaps in the Pathogenesis of Rosacea and Atherosclerosis

AU - Zavorins, Aleksejs

AU - Voicehovska, Julija

AU - Ķisis, Janis

AU - Lejnieks, Aivars

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Rosacea is a chronic inflammatory skin disease characterised by transient or persistent erythema, telangiectasia, papules, and pustules that predominantly involve central regions of the face. Recent studies have shown a possible clinical association between rosacea and cardiovascular diseases (CVDs). Rosacea and atherosclerosis are both known to have alterations in the innate immune system, enhanced oxidative and endoplasmic reticulum stress. The aim of this review is to delve deep into the pathogenesis of rosacea and atherosclerosis to uncover possible pathogenic overlaps between these chronic inflammatory diseases.

AB - Rosacea is a chronic inflammatory skin disease characterised by transient or persistent erythema, telangiectasia, papules, and pustules that predominantly involve central regions of the face. Recent studies have shown a possible clinical association between rosacea and cardiovascular diseases (CVDs). Rosacea and atherosclerosis are both known to have alterations in the innate immune system, enhanced oxidative and endoplasmic reticulum stress. The aim of this review is to delve deep into the pathogenesis of rosacea and atherosclerosis to uncover possible pathogenic overlaps between these chronic inflammatory diseases.

KW - atherosclerosis

KW - endoplasmic reticulum stress

KW - LL-37

KW - oxidative stress

KW - rosacea

KW - Toll-like receptor 2

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U2 - 10.2478/prolas-2018-0006

DO - 10.2478/prolas-2018-0006

M3 - Article

AN - SCOPUS:85049163610

SN - 1407-009X

VL - 72

SP - 152

EP - 159

JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

IS - 3

ER -

Overlaps in the Pathogenesis of Rosacea and Atherosclerosis

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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