Oxidation of cationic 1,4-dihydropyridine derivatives as model compounds for putative gene delivery agents

Aiva Plotniece, Karlis Pajuste, Dainis Kaldre, Brigita Cekavicus, Brigita Vigante, Baiba Turovska, Sergey Belyakov, Arkadij Sobolev, Gunars Duburs

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A new synthetic approach to cationic pyridine derivatives is described here. Two different strategies for the synthesis of 1,1′-{[3,5-bis(ethoxycarbonyl)-4-phenylpyridine-2,6-diyl]dimethylene}bispyridinium salts have been developed. The key step of the first strategy relies on electrochemical and chemical oxidation of cationic 1,4-dihydropyridines; the second one involves nucleophilic substitution of pyridine dibromo derivatives.

Original languageEnglish
Pages (from-to)8344-8349
Number of pages6
JournalTetrahedron
Volume65
Issue number40
DOIs
Publication statusPublished - 3 Oct 2009
Externally publishedYes

Keywords*

  • Cationic 1,4-dihydropyridines and pyridines
  • Gene delivery
  • Oxidation

Field of Science*

  • 1.4 Chemical sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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