OXIDATIVE STRESS INDUCED BY FREE RADICALS AND ITS CORRECTION BY USING ANTIOXIDANTS IN VIVO

Liga Larmane, Alise Silova, Georgijs Moisejevs, Ņina Rusakova, Andrejs Šķesters, Tija Zvagule

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Background: The aim of our study was to investigate if additional therapy of antioxidants (e.g. Se, α-tocopherol) may affect the reduction-oxidation (red-ox) state of the Chernobyl clean-up workers (ChCW) from Latvia. ChCW in comparison to people of the same age, gender and other criteria, suffer more chronic and oncological diseases and they are subjected to many chronic inflammatory processes that, in their turn, are related to free radical production and accordingly the red-ox state fluctuations.
Methods: Men of age 40 to 65 years (ChCW and healthy volunteers) were involved in the study. Each group received different combinations of antioxidants or placebo. Reduced glutathione (GSH), total antioxidant status, glutathione peroxidase (GSH-Px), Cu, Zn-superoxide dismutase (SOD) etc. and several lipid peroxidation (LPO) markers –
malondialdehyde etc. were detected in blood, plasma and erythrocytes.
Results: The results indicate that there is a tendency for LPO intensity to decrease during and after antioxidant therapy; in some patient groups, however, antioxidative defense improved by increase of Se and GSH, GSH-Px, SOD accordingly.
Conclusion: We cannot confirm that additional antioxidant therapy guarantees an
improvement in all cases related to higher free radical production, although our results demonstrate it may probably help to keep the red-ox state in balance.
Original languageEnglish
Article number191
Pages (from-to)539-540
JournalIn Vivo
Volume25
Issue number3
Publication statusPublished - Jun 2011
Event4TH INTERNATIONAL CONGRESS
OF MOLECULAR MEDICINE
- Istanbul, Turkey
Duration: 27 Jun 201130 Jun 2011

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)

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