Abstract
Background: The aim of our study was to investigate if additional therapy of antioxidants (e.g. Se, α-tocopherol) may affect the reduction-oxidation (red-ox) state of the Chernobyl clean-up workers (ChCW) from Latvia. ChCW in comparison to people of the same age, gender and other criteria, suffer more chronic and oncological diseases and they are subjected to many chronic inflammatory processes that, in their turn, are related to free radical production and accordingly the red-ox state fluctuations.
Methods: Men of age 40 to 65 years (ChCW and healthy volunteers) were involved in the study. Each group received different combinations of antioxidants or placebo. Reduced glutathione (GSH), total antioxidant status, glutathione peroxidase (GSH-Px), Cu, Zn-superoxide dismutase (SOD) etc. and several lipid peroxidation (LPO) markers –
malondialdehyde etc. were detected in blood, plasma and erythrocytes.
Results: The results indicate that there is a tendency for LPO intensity to decrease during and after antioxidant therapy; in some patient groups, however, antioxidative defense improved by increase of Se and GSH, GSH-Px, SOD accordingly.
Conclusion: We cannot confirm that additional antioxidant therapy guarantees an
improvement in all cases related to higher free radical production, although our results demonstrate it may probably help to keep the red-ox state in balance.
Methods: Men of age 40 to 65 years (ChCW and healthy volunteers) were involved in the study. Each group received different combinations of antioxidants or placebo. Reduced glutathione (GSH), total antioxidant status, glutathione peroxidase (GSH-Px), Cu, Zn-superoxide dismutase (SOD) etc. and several lipid peroxidation (LPO) markers –
malondialdehyde etc. were detected in blood, plasma and erythrocytes.
Results: The results indicate that there is a tendency for LPO intensity to decrease during and after antioxidant therapy; in some patient groups, however, antioxidative defense improved by increase of Se and GSH, GSH-Px, SOD accordingly.
Conclusion: We cannot confirm that additional antioxidant therapy guarantees an
improvement in all cases related to higher free radical production, although our results demonstrate it may probably help to keep the red-ox state in balance.
Original language | English |
---|---|
Article number | 191 |
Pages (from-to) | 539-540 |
Journal | In Vivo |
Volume | 25 |
Issue number | 3 |
Publication status | Published - Jun 2011 |
Event | 4th International Congress of Molecular Medicine - Istanbul, Turkey Duration: 27 Jun 2011 → 30 Jun 2011 Conference number: 4 https://www.klimik.org.tr/scientific/4th-international-congress-of-molecular-medicine/ |
Field of Science*
- 3.1 Basic medicine
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)