Current prospective clinical trial was conducted on 94 individuals, of them 57 with diagnosed MS and 37 almost healthy individuals. Anthropometric data, blood testing for MS and OS markers were assessed. We performed biopsy sampling of the skin for histologic evaluation in order to correlate serum OS marker levels with morphologic manifestations. MDA and SOD levels were higher in MS patients. Elevation of SOD positively correlated with all tested histologic signs of dermal degeneration, elastosis and sustained inflammation. OS biomarkers may be used in early MS identification in risk groups and for unfavourable course assessment.
|Journal||Comptes Rendus de L'Academie Bulgare des Sciences|
|Publication status||Published - 2018|
- oxidative stress
Field of Science
- 3.1 Basic medicine
- 3.2 Clinical medicine
- 1.1. Scientific article indexed in Web of Science and/or Scopus database