Oxidative stress markers diagnostic value in metabolic syndrome dermal manifestations: A prospective clinical trial

Metabolic syndrome (MS) is a combination of hormonal, metabolic and clinical disorders developing on the background of central obesity. Supposedly, oxidative stress (OS) takes central part in MS pathogenesis. It is suggested, that latent inflammation that accompanies MS is based on excessive amounts of free radicals. Skin is under constant external factor influence which initiates free radical reactions with following lipid peroxidation, protein and DNA oxidative damage. Combining external and MS induced changes, skin manifestations may provide insight on dermal antioxidative capacity and OS. Aim of current study is to evaluate correlations of OS parameters and dermal MS manifestations.
Current prospective clinical trial was conducted on 94 individuals, of them 57 with diagnosed MS and 37 almost healthy individuals. Anthropometric data, blood testing for MS and OS markers were assessed. We performed biopsy sampling of the skin for histologic evaluation in order to correlate serum OS marker levels with morphologic manifestations. MDA and SOD levels were higher in MS patients. Elevation of SOD positively correlated with all tested histologic signs of dermal degeneration, elastosis and sustained inflammation. OS biomarkers may be used in early MS identification in risk groups and for unfavourable course assessment.