TY - JOUR
T1 - Oxidized chitosan modified electrospun scaffolds for controllable release of acyclovir
AU - Shekh, Mehdihasan I.
AU - Amirian, Jhaleh
AU - Stadler, Florian J.
AU - Du, Bing
AU - Zhu, Yanxia
N1 - Funding Information:
This research was funded by Shenzhen Fundamental Research Funds ( JCYJ20170302145500980 , JCYJ20170818100526471 , KQJSCX20180328095512554 ), Medical Scientific Research Foundation of Guangdong Province ( A2018555 ), Nanshan District Key Lab for Biopolymers and Safety Evaluation ( KC2014ZDZJ0001A ) and Shenzhen Sci & Tech research grant ( ZDSYS201507141105130 ).
Funding Information:
This research was funded by Shenzhen Fundamental Research Funds ( JCYJ20170302145500980 , JCYJ20170818100526471 , KQJSCX20180328095512554 ), Medical Scientific Research Foundation of Guangdong Province ( A2018555 ), Nanshan District Key Lab for Biopolymers and Safety Evaluation ( KC2014ZDZJ0001A ) and Shenzhen Sci & Tech research grant ( ZDSYS201507141105130 ).
Publisher Copyright:
© 2020
PY - 2020/5/15
Y1 - 2020/5/15
N2 - Developing a novel scaffold carrier with a sustained and controllable release profile of drug is essential to promote the effective transdermal delivery for acyclovir (ACY). In this work, electrospun polyacrylonitrile nanofibers (PAN NFs) was chemically modified with oxidized chitosan (OC). The modified fibrous scaffold was further loaded with the ACY for drug released investigation. FT-IR and NMR results revealed that the conversion of the functional group for each step has successfully occurred on the surface of the fibers. Through the in-vitro drug release and kinetic study, it demonstrated that ACY could be sustainably and controlled released from the OC modified scaffold following the Korsmeyer-Peppas model with a Fickian diffusion mechanism. The human adipose-derived stem cells and the blood combability evaluation confirmed the obtained scaffold possessed excellent cell biocompatibility and hemocompatibility. It could be concluded that the resultant OC modified scaffold based on electrospun PAN NFs opened a new potential option for the topical/transdermal drug delivery of ACY.
AB - Developing a novel scaffold carrier with a sustained and controllable release profile of drug is essential to promote the effective transdermal delivery for acyclovir (ACY). In this work, electrospun polyacrylonitrile nanofibers (PAN NFs) was chemically modified with oxidized chitosan (OC). The modified fibrous scaffold was further loaded with the ACY for drug released investigation. FT-IR and NMR results revealed that the conversion of the functional group for each step has successfully occurred on the surface of the fibers. Through the in-vitro drug release and kinetic study, it demonstrated that ACY could be sustainably and controlled released from the OC modified scaffold following the Korsmeyer-Peppas model with a Fickian diffusion mechanism. The human adipose-derived stem cells and the blood combability evaluation confirmed the obtained scaffold possessed excellent cell biocompatibility and hemocompatibility. It could be concluded that the resultant OC modified scaffold based on electrospun PAN NFs opened a new potential option for the topical/transdermal drug delivery of ACY.
KW - Drug carrier
KW - Electrospun nanofibrous scaffold
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=85080074203&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/abs/pii/S0141813020304864?via%3Dihub
U2 - 10.1016/j.ijbiomac.2020.02.230
DO - 10.1016/j.ijbiomac.2020.02.230
M3 - Article
C2 - 32092427
AN - SCOPUS:85080074203
SN - 0141-8130
VL - 151
SP - 787
EP - 796
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -