Oxidized chitosan modified electrospun scaffolds for controllable release of acyclovir

Mehdihasan I. Shekh, Jhaleh Amirian, Florian J. Stadler, Bing Du (Coresponding Author), Yanxia Zhu (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Developing a novel scaffold carrier with a sustained and controllable release profile of drug is essential to promote the effective transdermal delivery for acyclovir (ACY). In this work, electrospun polyacrylonitrile nanofibers (PAN NFs) was chemically modified with oxidized chitosan (OC). The modified fibrous scaffold was further loaded with the ACY for drug released investigation. FT-IR and NMR results revealed that the conversion of the functional group for each step has successfully occurred on the surface of the fibers. Through the in-vitro drug release and kinetic study, it demonstrated that ACY could be sustainably and controlled released from the OC modified scaffold following the Korsmeyer-Peppas model with a Fickian diffusion mechanism. The human adipose-derived stem cells and the blood combability evaluation confirmed the obtained scaffold possessed excellent cell biocompatibility and hemocompatibility. It could be concluded that the resultant OC modified scaffold based on electrospun PAN NFs opened a new potential option for the topical/transdermal drug delivery of ACY.

Original languageEnglish
Pages (from-to)787-796
Number of pages10
JournalInternational Journal of Biological Macromolecules
Publication statusPublished - 15 May 2020
Externally publishedYes


  • Drug carrier
  • Electrospun nanofibrous scaffold
  • Surface modification

Field of Science*

  • 1.4 Chemical sciences
  • 2.10 Nano-technology
  • 2.5 Materials engineering
  • 2.11 Other engineering and technologies

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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