Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)

Dragos Vinereanu, Dmitry Napalkov, Jutta Bergler-Klein, Bela Benczur, Martin Ciernik, Nina Gotcheva, Alexey Medvedchikov, Pentti Põder, Dragan Simic, Andris Skride, Wenbo Tang, Maria Trusz-Gluza, Jiri Vesely, Tatiana Vishnepolsky, Mirej Vrabec (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Objective We evaluated atrial fibrillation (AF) patients' perceptions of anticoagulation treatment with dabigatran or a vitamin K antagonist (VKA) for stroke prevention, according to accepted indications. Methods The RE-SONANCE observational, prospective, multicentre, international study used the validated Perception on Anticoagulant Treatment Questionnaire (PACT-Q) to assess patients with AF already taking a VKA who were switched to dabigatran (cohort A), and newly diagnosed patients initiated on either dabigatran or a VKA (cohort B). Visit 1 (V1) was at baseline, and visit 2 (V2) and visit 3 (V3) were at 30-45 and 150-210 days after baseline, respectively. Primary outcomes were treatment satisfaction and convenience in cohort A at V2 and V3 versus baseline, and in cohort B for dabigatran and a VKA at V2 and V3. Results The main analysis set comprised 4100 patients in cohort A and 5365 in cohort B (dabigatran: 3179; VKA: 2186). In cohort A, PACT-Q2 improved significantly (p<0.001 for all) for treatment convenience (mean change V1 vs V2=20.72; SD=21.50; V1 vs V3=24.54; SD=22.85) and treatment satisfaction (mean change V1 vs V2=17.60; SD=18.76; V1 vs V3=21.04; SD=20.24). In cohort B, mean PACT-Q2 scores at V2 and V3 were significantly higher (p<0.001 for all) for dabigatran versus a VKA for treatment convenience (V2=18.38; SE =0.51; V3=23.34; SE=0.51) and satisfaction (V2=15.88; SE=0.39; V3=19.01; SE=0.41). Conclusions Switching to dabigatran from long-term VKA therapy or newly initiated dabigatran is associated with improved patient treatment convenience and satisfaction compared with VKA therapy.

Original languageEnglish
Article numbere001202
Pages (from-to)1-9
Number of pages9
JournalOpen Heart
Issue number1
Publication statusPublished - 24 Mar 2020


  • atrial fibrillation
  • quality of care and outcomes
  • stroke

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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