Abstract
Objectives: Dexmedetomidine is known to prolong the duration of regional block while its
sedative effect when administered perineurally is unknown. We aim to evaluate the effect of
perineural Dexmedetomidine on the systemic sedation in patients after axillary brachial
plexus block (ABPB).
Materials and Methods: This prospective randomized control trial includes 80 patients
undergoing wrist surgery receiving ABPB. The study was conducted with the approval of
Ethics Committee of Riga Stradins University. Patients were randomized into two groups -
control (CG) (N=40) and study group (SG) (N=40). Both groups received ABPB with a
standard dose of local anaesthetics. The study group also received 100 mcg of
dexmedetomidine perineurally. Depth of sedation during surgery was evaluated using
electroencephalography with Narcontrend Index (NI) and Ramsay Sedation Scale (RSS).
Patient satisfaction with sedation was evaluated using a postoperative survey.
Results: During 10 to 60 minutes after ABPB the median RSS was 4 and median NI was
between 54 to 69 in SG. Median RSS decreased to 2 and median NI increased to 90 in 90
minutes after ABPB in SG. Patients in the CG had the median RSS of 2 and Narcotrend
Index of 97 all throughout surgery. (p=0.001) No significant differences in hemodynamic or
respiratory parameters were found between the groups. Patients in the SG expressed
satisfaction with quality of sedation and 86.5% noted that the sensation was similar to
ordinary sleep.
Conclusions: Perineural administration of Dexmedetomidine provides systemic sedation
with no effect on hemodynamic or respiratory stability and yields a high level of patient
satisfaction.
sedative effect when administered perineurally is unknown. We aim to evaluate the effect of
perineural Dexmedetomidine on the systemic sedation in patients after axillary brachial
plexus block (ABPB).
Materials and Methods: This prospective randomized control trial includes 80 patients
undergoing wrist surgery receiving ABPB. The study was conducted with the approval of
Ethics Committee of Riga Stradins University. Patients were randomized into two groups -
control (CG) (N=40) and study group (SG) (N=40). Both groups received ABPB with a
standard dose of local anaesthetics. The study group also received 100 mcg of
dexmedetomidine perineurally. Depth of sedation during surgery was evaluated using
electroencephalography with Narcontrend Index (NI) and Ramsay Sedation Scale (RSS).
Patient satisfaction with sedation was evaluated using a postoperative survey.
Results: During 10 to 60 minutes after ABPB the median RSS was 4 and median NI was
between 54 to 69 in SG. Median RSS decreased to 2 and median NI increased to 90 in 90
minutes after ABPB in SG. Patients in the CG had the median RSS of 2 and Narcotrend
Index of 97 all throughout surgery. (p=0.001) No significant differences in hemodynamic or
respiratory parameters were found between the groups. Patients in the SG expressed
satisfaction with quality of sedation and 86.5% noted that the sensation was similar to
ordinary sleep.
Conclusions: Perineural administration of Dexmedetomidine provides systemic sedation
with no effect on hemodynamic or respiratory stability and yields a high level of patient
satisfaction.
| Original language | English |
|---|---|
| Pages (from-to) | A83 |
| Number of pages | 1 |
| Journal | Regional Anesthesia and Pain Medicine |
| Volume | 70 |
| Issue number | S1 |
| Publication status | Published - 9 Sept 2021 |
| Event | Annual Congress of the European Society of Regional Anaesthesia (ESRA 2021) - virtual, Switzerland Duration: 8 Sept 2021 → 10 Sept 2021 https://esra2021.com |
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)