Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy

Marcis Leja, Sanita Lapina, Inese Polaka, Dace Rudzite, Ilona Vilkoite, Ilva Daugule, Anna Belkovets, Sergey Pimanov, Jelena Makarenko, Ivars Tolmanis, Aivars Lejnieks, Viesturs Boka, Ingrida Rumba-Rozenfelde, Uldis Vikmanis

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
4 Downloads (Pure)


Background and objective: Pepsinogen levels in plasma are increased by inflammation in the gastric mucosa, including inflammation resulting from Helicobacter pylori infection. A decrease in pepsinogen II level has been suggested as a reliable marker to confirm the successful eradication of infection. The aim of our study was to evaluate the potential role of pepsinogens I and II, gastrin-17 and H. pylori antibodies in confirming successful eradication. Material and methods: Altogether 42 patients (25 women, 17 men), mean age 45 years (range 23-74), were enrolled. Pepsinogens I and II, gastrin-17 and H. pylori IgG antibodies were measured in plasma samples using an ELISA test (Biohit, Oyj., Finland) before the eradication and 4 weeks after completing the treatment. The success of eradication was determined by a urea breath test. Results: Eradication was successful in 31 patients (74%) and unsuccessful in 11 patients (26%). Pepsinogen II decreased significantly in both the successful (P = 0.029) and unsuccessful (P = 0.042) eradication groups. Pepsinogen I decreased significantly in the successful (P = 0.025) but not the unsuccessful (P = 0.29) eradication group. The pepsinogen I/II ratio increased in the successful eradication group (P = 0.0018) but not in the group in which treatment failed (P = 0.12). There were no differences in gastrin-17 or H. pylori antibody values. Conclusions: A decrease in pepsinogen II levels cannot be used as a reliable marker for the successful eradication of H. pylori 4 weeks after the completion of treatment. The increase in pepsinogen I/II ratio reflects differences in pepsinogen production following the eradication irrespective of improvement in atrophy.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalMedicina (Lithuania)
Issue number1
Publication statusPublished - 2014


  • Efficacy
  • Eradication
  • Gastrin-17
  • Helicobacter pylori
  • Pepsinogen

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


Dive into the research topics of 'Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy'. Together they form a unique fingerprint.

Cite this