Performance of routine Helicobacter pylori tests in patients with atrophic gastritis

Agnese Sudraba, Ilva Daugule, Dace Rudzite, Konrads Funka, Ivars Tolmanis, Lars Engstrand, Dainius Janciauskas, Laimas Jonaitis, Gediminas Kiudelis, Limas Kupcinskas, Audrius Ivanauskas, Marcis Leja

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background. Decreased density of H.pylori in atrophic gastritis may lead to low sensitivity of the routine tests. Aims. To evaluate the accuracy of routinely used H.pylori tests in atrophic gastritis. Methods. We compared 5 H.pylori diagnostic tests in 119 dyspeptic patients (28 males/91 females) with a mean age of 67 years (range 55-84). Patients with gastric cancer, peptic ulcer, previous gastric surgery, or those who have received eradication therapy were excluded. The following tests were performed: histology, rapid urease test (RUT), culture, 13C- urease breath tests (UBT), and H.pylori IgG/IgA antibody test (serology). Results. Atrophic gastritis was diagnosed in 26.1% of the patients; H.pylori was present in 87.1%. In the group with atrophy, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were as follows: histology (100% for all parameters); UBT (96; 100; 100; 80; 97%); serology (96; 50; 93; 67; 90%); culture (96; 100; 100; 80; 97%); and RUT (78; 100; 100; 40; 81%), respectively. Conclusions. Histology, UBT and culture were the three best tests for diagnosing H.pylori infection. We cannot recommend using serology as a single test in a case of atrophy, but it would be reasonable to combine serology with one of the above tests.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalJournal of Gastrointestinal and Liver Diseases
Issue number4
Publication statusPublished - Dec 2011
Externally publishedYes


  • C urease breath test
  • Atrophic gastritis
  • Culture
  • Helicobacter pylori
  • Histology
  • Rapid urease test
  • Serology

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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