Pharmacological evaluation of nasal delivery of selegiline hydrochloride-loaded thiolated chitosan nanoparticles for the treatment of depression

Devendra Singh, Muzamil Rashid, Supandeep Singh Hallan, Neelesh Kumar Mehra, Atish Prakash, Neeraj Mishra

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The aim of the present study was to investigate the propensity of thiolated chitosan nanoparticles (TCNs) to enhance the nasal delivery of selegiline hydrochloride. TCNs were synthesized by the ionic gelation method. The particle size distribution (PDI), entrapment efficiency (EE), and zeta potential of modified chitosan (CS) nanoparticles were found to be 215 ± 34.71 nm, 70 ± 2.71%, and + 17.06 mV, respectively. The forced swim and the tail suspension tests were used to evaluate the anti-depressant activity, in which elevated immobility time was found to reduce on treatment. TCNs seem to be promising candidates for nose-to-brain delivery in the evaluation of antidepressant activity.

Original languageEnglish
Pages (from-to)865-877
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume44
Issue number3
DOIs
Publication statusPublished - Apr 2016
Externally publishedYes

Keywords*

  • depression
  • nasal delivery
  • selegiline hydrochloride
  • thiolated chitosan nanoparticles

Field of Science*

  • 3.1 Basic medicine
  • 3.4 Medical biotechnology

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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