Pharmacological properties of polyphenols: Bioavailability, mechanisms of action and biological effects in in vitro studies, animal models and humans

Kristine Stromsnes, Rudīte Lagzdiņa, Gloria Olaso‐Gonzalez, Lucia Gimeno‐Mallench, Juan Gambini (Coresponding Author)

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
2 Downloads (Pure)

Abstract

Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.

Original languageEnglish
Article number1074
Number of pages26
JournalBiomedicines
Volume9
Issue number8
DOIs
Publication statusPublished - Aug 2021

Keywords*

  • Bioavailability
  • Biological effects
  • Concomitant
  • Drugs
  • Human
  • In vitro
  • In vivo
  • Mechanisms of action
  • Pharmacological
  • Polyphenol

Field of Science*

  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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