TY - JOUR
T1 - Pharmacological properties of polyphenols
T2 - Bioavailability, mechanisms of action and biological effects in in vitro studies, animal models and humans
AU - Stromsnes, Kristine
AU - Lagzdiņa, Rudīte
AU - Olaso‐Gonzalez, Gloria
AU - Gimeno‐Mallench, Lucia
AU - Gambini, Juan
N1 - Funding Information:
Funding: This work was supported by the following grants from the Instituto de Salud Carlos III CB16/10/00435 (CIBERFES), (PID2019‐110906RB‐I00/AEI/10.13039/501100011033) from the Spanish Ministry of Innovation and Science, PROMETEO/2019/097 de “Consellería, de Sanitat de la Gener‐ alitat Valenciana”, and the EU Funded H2020‐DIABFRAIL‐LATAM (Ref: 825546), European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL), and of the ERA‐NET Co‐ fund ERA‐HDHL (GA No. 696295 of the EU Horizon 2020 Research and Innovation Program). Part of the equipment employed in this work has been funded by Generalitat Valenciana and co‐financed with ERDF funds (OP ERDF of Comunitat Valenciana 2014–2020).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/8
Y1 - 2021/8
N2 - Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.
AB - Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.
KW - Bioavailability
KW - Biological effects
KW - Concomitant
KW - Drugs
KW - Human
KW - In vitro
KW - In vivo
KW - Mechanisms of action
KW - Pharmacological
KW - Polyphenol
UR - http://www.scopus.com/inward/record.url?scp=85113377731&partnerID=8YFLogxK
U2 - 10.3390/biomedicines9081074
DO - 10.3390/biomedicines9081074
M3 - Review article
AN - SCOPUS:85113377731
SN - 2227-9059
VL - 9
JO - Biomedicines
JF - Biomedicines
IS - 8
M1 - 1074
ER -
