Phlogenzym (R) may prevent metabolic injuries to myocardium. Results of a laboratory experiment with rats

To evaluate the possible cardio- and angioprotective efficacy of an orally administered enzyme preparation, Phlogenzym((R)), an experiment with laboratory animals was carried out. Metabolic injury to myocardium was initiated by injection of epinephrine. Morphological changes in tissue isolated from the hearts of control group animals were more marked compared with those in tissue from Phlogenzym((R))- treated animals. Furthermore, higher expression of transforming growth factor-P and more collagen fibers were found in tissue from the hearts of control animals. The least expressed changes were seen in tissue from animals pretreated and further treated with Phlogenzym((R)). We suggest that our findings support the assumption that Phlogenzym((R)) may prevent metabolic injury to myocardium, improve physiological tissue repair and prevent fibrosis formation.