Plasma NO-binding activity in patients with hematological malignancies: Suppressive effect of glucocorticoids

V. I. Petukhov, I. Ya Kalvinsh, I. K. Shestakova, I. A. Domracheva, I. Ya Kanepe, R. G. Stibel, M. A. Romanova, Andrejs P. Skesters

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma NO-binding activity was studied in patients with various forms of hematological malignancies. The method used in the study quantitatively evaluated the plasma capacity to bind NO, which reflects the intensity of NO production and the degree of patient's stress resistance. Plasma NO-binding activity significantly decreases in patients with hematological malignancies. Glucocorticoid treatment promotes the decrease in plasma NO-binding activity, which was dose-dependent.

Original languageEnglish
Pages (from-to)614-617
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume142
Issue number5
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Glucocorticoids
  • Nitrogen oxide
  • Plasma NO binding activity

Field of Science

  • 1.6 Biological sciences
  • 1.4 Chemical sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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