Plasma Rich in Growth Factors (PRGF) in Transepithelial Photorefractive Keratectomy (TPRK)

Jose-Maria Sanchez-Gonzalez (Coresponding Author), Federico Alonso-Aliste, Davide Borroni, Jonatan Amian-Cordero, Concepcion De-Hita-Cantalejo, Raul Capote-Puente, Maria-Jose Bautista-Llamas, Maria Carmen Sanchez-Gonzalez, Marina Rodriguez-Calvo-de-Mora, Carlos Rocha-de-Lossada

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    2 Citations (Scopus)
    3 Downloads (Pure)


    To evaluate the usage of plasma rich in growth factor (PRGF) in transepithelial photorefractive keratectomy (TPRK) in low and moderate myopia, patients who underwent myopic and
    astigmatism TPRK with PRGF were involved in this retrospective, observational study. Subjects
    underwent a surgical procedure between February 2019 and June 2019. A three-month follow-up
    was recorded. Pain score was assessed with a visual analogue scale (0–10) and re-epithelialization
    time recorded. A total of 48 eyes from 24 patients were recruited. Mean uncorrected distance visual
    acuity (UDVA) was 20/20.31 (0.00 ± 0.02 LogMAR). A total of 98% of eyes did not change corrected
    distance visual acuity (CDVA) lines. Two percent of eyes lost one line of CDVA. Preoperative spherical equivalent was −2.67 ± 1.37 D and after three months changed to −0.21 ± 0.34 D, and 2% of
    eyes changed 0.50 D or more between one and three months. Pain score was 3.29 ± 0.61 (3 to 6)
    score points at day one and 0.08 ± 0.27 score points at day seven. Finally, re-epithelialization time
    was 2.50 ± 1.20 days. PRGF addition to conventional refractive treatment such as TPRK seems to
    alleviate immediate postoperative pain and positively contribute to corneal re-epithelization time.
    Original languageEnglish
    Article number 1939
    Number of pages9
    JournalJournal of clinical medicine
    Issue number9
    Publication statusPublished - May 2021


    • plasma rich in growth factor
    • photorefractive keratectomy
    • transepithelial photorefractive keratectomy
    • visual outcomes
    • refractive outcomes

    Field of Science*

    • 3.2 Clinical medicine

    Publication Type*

    • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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