Platelet rich fibrin perspectives in orthognatic surgery

Orthognatic surgery is a common treatment approach for severe dentofacial deformities. Despite favorable result and development of 3D planning to get predictable outcomes, still remains adverse results after jaw repositioning. Literature review was done using articles searched in PubMed (National Library of Medicine) using key words. Articles were screened by title and abstract, including publishing years from 2009. 16 full text articles were analysed. Articles were cited using PubMed citation in AMA format. Skeletal stability of the osteotomy sites is dependent on the quality of bone union. After large mandibular movement, insufficient bone contact may result in bony defect in mandible and can create unpleasant mandibular notching or lower border irregularities. To improve bone healing variable biomaterials are used. No studies were found about PRF use directly in orthognatic surgery. Mostly studies showed stimulating effect on bone formation in single staged implant placement in maxillary frontal zone, after 3rd molar extraction However, some researches showed no significant effect on bone formation (sinus augmentation) and no stable effect using PRF alone. There is a lack of evidence in literature regarding PRF application for the osteotomy sites in orthognatic surgery. PRF may be useful in solving insufficient bone formation problem, to avoid mandibular contour defect. Besides it is necessary to evaluate PRF antibacterial and antifungal effect which can influence compromised bone healing and may lead to bone formation improvement. Further careful researches are needed. The authors acknowledge financial support from the Latvian Council of Science research project No. lzp-2020/1-0054 “Development of antibacterial autologous fibrin matrices in maxillofacial surgery (MATRI-X)”.