Polyols as a sustainable solution in oral drug delivery systems

Elzbieta Maria Buczkowska; Zoltan Mark Horvath; Kirils Kukuls; Alīna Jaroslava Frolova; Līga Pētersone; Valentyn Mohylyuk

doi:10.13140/RG.2.2.10911.83364

Polyols as a sustainable solution in oral drug delivery systems

Elzbieta Maria Buczkowska
, Zoltan Mark Horvath
, Kirils Kukuls
, Alīna Jaroslava Frolova
, Līga Pētersone^*
, Valentyn Mohylyuk

^*Corresponding author for this work

Research output: Contribution to conference › Poster

6 Downloads (Pure)

Original language	English
DOIs	https://doi.org/10.13140/RG.2.2.10911.83364
Publication status	Published - 26 Sept 2025
Event	15th Central European Symposium on Pharmaceutical Technology - Bled, Slovenia Duration: 25 Sept 2025 → 27 Sept 2025 Conference number: 15 https://www.sfd.si/cespt2025/programme/scientific-programme/

Symposium

Symposium	15th Central European Symposium on Pharmaceutical Technology
Abbreviated title	15th CESPT
Country/Territory	Slovenia
City	Bled
Period	25/09/25 → 27/09/25
Internet address	https://www.sfd.si/cespt2025/programme/scientific-programme/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure
SDG 11 Sustainable Cities and Communities

Keywords*

polyols
green chemistry
physicochemical properties
Intrinsic dissolution rate
mannitol
isomalt
sorbitol
Xylitol
moisture
FTIR
Karl Fisher titration
pKa

Field of Science

3.1 Basic medicine
2.5 Materials engineering
2.4 Chemical engineering
1.4 Chemical sciences

Publication Type*

3.4. Other publications in conference proceedings (including local)

Access to Document

10.13140/RG.2.2.10911.83364

Polyols as a sustainable solution in oral drug delivery systemsFinal published version, 1.13 MB

3 Poster
1 Article

High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol
Buczkowska, E. M., Kukuls, K., Horvath, Z. M., Frolova, A. J., Pētersone, L., Dadou, S. & Mohylyuk, V., 26 Mar 2026.
Research output: Contribution to conference › Poster › peer-review

Open Access
Determination of polyols' intrinsic dissolution rate as an important characteristic for pre- and formulation
Buczkowska, E. M., Frolova, A. J., Kukuls, K., Horvath, Z. M., Žogota, M., Pētersone, L. & Mohylyuk, V., Jun 2025. 1 p.
Research output: Contribution to conference › Poster

Open Access
File

7 Downloads (Pure)
Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder
Horvath, Z. M., Kukuls, K., Frolova, A. J., Žogota, M., Buczkowska, E. M., Pētersone, L. & Mohylyuk, V., 21 May 2025, In: Pharmaceutics. 17, 5, 15 p., 676.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

13 Downloads (Pure)

1 Finished

Suitability of sugar alcohols (polyols) as binders in twin-screw melt granulation for preparation of high-drug-loaded immediate-release tablets with superior mechanical properties
Mohylyuk, V. (Project leader), Buczkowska, E. M. (Member of project working group), Pētersone, L. (Member of project working group), Žogota, M. (Member of project working group), Horvath, Z. M. (Member of project working group), Kukuls, K. (Member of project working group) & Frolova, A. J. (Member of project working group)
European Commission
1/04/24 → 31/03/26
Project: Research and development projects financed by the Latvian state budget › Other projects financed by the Latvian state budget

Karl Fischer (KF) Titration of Polyols
Frolova, A. J. (Creator), Kukuls, K. (Creator), Horvath, Z. M. (Creator), Gniazdowska, E. M. (Creator), Pētersone, L. (Creator), Mohylyuk, V. (Creator) & Buczkowska, E. M. (Creator), Rīga Stradiņš University Institutional Repository Dataverse, 17 Mar 2025
DOI: 10.48510/fk2/4areio, https://doi.org/10.48510/FK2/4AREIO and one more link, https://dataverse.rsu.lv/dataset.xhtml?persistentId=doi:10.48510/FK2/4AREIO (show fewer)
Dataset
Loss on Drying (LoD) of Polyols
Frolova, A. J. (Creator), Kukuls, K. (Creator), Horvath, Z. M. (Creator), Gniazdowska, E. M. (Creator) & Mohylyuk, V. (Creator), Rīga Stradiņš University Institutional Repository Dataverse, 21 Jan 2025
DOI: 10.48510/FK2/XILW3Z, https://dataverse.rsu.lv/dataset.xhtml?persistentId=doi:10.48510/FK2/XILW3Z
Dataset
Intrinsic Dissolution Rate (IDR) of Polyols
Gniazdowska, E. M. (Creator), Frolova, A. J. (Creator), Kukuls, K. (Creator), Horvath, Z. M. (Creator) & Mohylyuk, V. (Creator), Rīga Stradiņš University Institutional Repository Dataverse, 6 Feb 2025
DOI: 10.48510/FK2/BJPEC8, https://dataverse.rsu.lv/dataset.xhtml?persistentId=doi:10.48510/FK2/BJPEC8
Dataset

Cite this

@conference{935c57d02d1e4160903b176c70128e36,

title = "Polyols as a sustainable solution in oral drug delivery systems",

keywords = "polyols, green chemistry, physicochemical properties, Intrinsic dissolution rate, mannitol, isomalt, sorbitol, Xylitol, moisture, FTIR, Karl Fisher titration, pKa",

author = "Buczkowska, \{Elzbieta Maria\} and Horvath, \{Zoltan Mark\} and Kirils Kukuls and Frolova, \{Alīna Jaroslava\} and Līga Pētersone and Valentyn Mohylyuk",

year = "2025",

month = sep,

day = "26",

doi = "10.13140/RG.2.2.10911.83364",

language = "English",

note = "15th Central European Symposium on Pharmaceutical Technology, 15th CESPT ; Conference date: 25-09-2025 Through 27-09-2025",

url = "https://www.sfd.si/cespt2025/programme/scientific-programme/",

}

TY - CONF

T1 - Polyols as a sustainable solution in oral drug delivery systems

AU - Buczkowska, Elzbieta Maria

AU - Horvath, Zoltan Mark

AU - Kukuls, Kirils

AU - Frolova, Alīna Jaroslava

AU - Pētersone, Līga

AU - Mohylyuk, Valentyn

N1 - Conference code: 15

PY - 2025/9/26

Y1 - 2025/9/26

KW - polyols

KW - green chemistry

KW - physicochemical properties

KW - Intrinsic dissolution rate

KW - mannitol

KW - isomalt

KW - sorbitol

KW - Xylitol

KW - moisture

KW - FTIR

KW - Karl Fisher titration

KW - pKa

U2 - 10.13140/RG.2.2.10911.83364

DO - 10.13140/RG.2.2.10911.83364

M3 - Poster

T2 - 15th Central European Symposium on Pharmaceutical Technology

Y2 - 25 September 2025 through 27 September 2025

ER -

Polyols as a sustainable solution in oral drug delivery systems

Symposium

UN SDGs

Keywords*

Field of Science

Publication Type*

Access to Document

Research output

High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol

Determination of polyols' intrinsic dissolution rate as an important characteristic for pre- and formulation

Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder

Projects

Suitability of sugar alcohols (polyols) as binders in twin-screw melt granulation for preparation of high-drug-loaded immediate-release tablets with superior mechanical properties

Datasets

Karl Fischer (KF) Titration of Polyols

Loss on Drying (LoD) of Polyols

Intrinsic Dissolution Rate (IDR) of Polyols

Cite this