Porous hydroxyapatite bioceramic scaffolds for drug delivery and bone regeneration

Dagnija Loca, Janis Locs, Kristine Salma, Juris Gulbis, Ilze Salma, Liga Berzina-Cimdina

Research output: Contribution to journalConference articlepeer-review

12 Citations (Scopus)

Abstract

The conventional methods of supplying a patient with pharmacologic active substances suffer from being very poorly selective, so that damage can occurs to the healthy tissues and organs, different from the intended target. In addition, high drug doses can be required to achieve the desired effect. An alternative approach is based on the use of implantable delivery tools, able to release the active substance in a controlled way. In the current research local drug delivery devices containing 8mg of gentamicin sulphate were prepared using custom developed vacuum impregnation technique. In vitro dissolution tests showed that gentamicin release was sustained for 12h. In order to decrease gentamicin release rate, biopolymer coatings were applied and coating structure investigated. The results showed that gentamicin release can be sustained for more than 70h for poly(-caprolactone) coated calcium phosphate scaffolds. From poly lactic acid and polyvinyl alcohol coated scaffolds gentamicin was released within 20h and 50h, respectively.

Original languageEnglish
Article number192019
JournalIOP Conference Series: Materials Science and Engineering
Volume18
Issue number Ceramics for Medicine, Biotechnology and Biomimetics
DOIs
Publication statusPublished - 2011
Externally publishedYes
Event3rd International Congress on Ceramics, ICC3 - Osaka, Japan
Duration: 14 Nov 201018 Nov 2010

Field of Science*

  • 2.5 Materials engineering
  • 3.4 Medical biotechnology

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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