Possible interference of human betaherpesviruses-6 and -7 in gastrointestinal cancer development

A. Sultanova (Coresponding Author), M. Chistjakovs, S. Chapenko, S. Donina, M. Murovska

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastrointestinal cancer. Methods: Sixty five patients with gastrointestinal cancer before surgery and without any treatment were enrolled in this study and divided into two groups depending on lymphocytes' count: I group (n = 35) - lymphocytes > 1400x106/L and II group (n = 30) - lymphocytes < 1400x106/L. Nested polymerase chain reaction was used to detect latent and active stage of persistent human herpesvirus-6 and -7 infection, laser flow cytometry with monoclonal antibodies - to determine immunological parameters. Results: Activation of herpesvirus-6 and -7 was more frequently observed in the patients' group with lymphopenia (HHV-6 1/1 (100%), HHV-7 4/8 (50%) and HHV-6 + HHV-7 6/9 (66%); p < 0.05). Cellular immune parameters were analysed in immunocompromised II group's patients dependently on beta-herpevirus infection. Although number of leukocytes was higher in patients with active HHV-6/-7 infection (p = 0.01), number of lymphocytes CD3+, CD4+, CD8+ and CD38+ in patients with active HHV-6/-7 infection tended to decrease (p < 0.0001, P = 0.0002, p = 0.0001 and p < 0.0001, respectively). However, number of CD19+ had tendency to increase (p = 0.03). Conclusion: Activation of herpesvirus-6 and -7 may lead to decrease of lymphocytes total count and develop immunosuppression in patients with gastrointestinal cancer.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalExperimental Oncology
Volume35
Issue number2
Publication statusPublished - Jun 2013

Keywords

  • Beta-herpesvirus-6
  • Beta-herpesvirus-7
  • Gastrointestinal cancer

Field of Science

  • 3.2 Clinical medicine
  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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