Potential role of total antioxidant status ratio in differential diagnosis of pleural effusion

Dace Dubava, Madara Tirzite, Inga Stukena, Alvils Krams, Aivars Lejnieks

Research output: Contribution to journalMeeting Abstractpeer-review


There is various data in literature on the connection of pulmonary diseases with oxidative stress, only
a few papers have been published on the role of antioxidative system and its activity in cases of pleural
pathologies. Investigations have shown that in parapneumonic effusions the level of some antioxidants is
higher than in transudates, malignant or tuberculous exudates. Their level increases even more in cases of
empyema and complicated parapneumonic effusions. The aim of the study was to evaluate the possible use
of total antioxidant status (TAS) pleural fluid/serum ratio. 73 patients were enrolled in the study, 17 had
transudate, 37 malignant and 19 inflammatory effusions. TAS was measured both in serum and pleural fluid
by Randox©TAS kit. Results: statistical analysis was done using ANOVA programme with Post HOC test
(Bonferoni). TAS ratio correlated significantly with Light’s criteria. Mean pleural fluid/serum ratio was the
highest in cases of inflammatory effusions, the lowest in trasudates. TAS ratio mean value of transudates
statistically significantly differ from inflammatory effusions (p=0.02) while the difference between the other
groups was not statistically significant. Conclusion: TAS ratio can be used to distinguish transudates from
inflammatory effusions. Further investigations are necessary to precise the role of antioxidants and oxidative
stress in cases of pleural effusions.
Original languageEnglish
Article number1764
JournalEuropean Respiratory Journal
Issue numberSuppl.57
Publication statusPublished - 1 Sep 2013
EventEuropean Respiratory Society Annual Congress 2013 - Barcelona, Spain
Duration: 7 Sep 201311 Sep 2013


  • Pleura
  • Biomarkers

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

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