Preparation of eco-friendly eutectic solvents to improve the solubility of drugs

Katarīna Gurkina; Rihards Mahinovs; Līga Pētersone; Valentyn Mohylyuk

doi:10.13140/RG.2.2.29113.84323

Preparation of eco-friendly eutectic solvents to improve the solubility of drugs

Katarīna Gurkina
, Rihards Mahinovs
, Līga Pētersone (Corresponding Author)
, Valentyn Mohylyuk

Lead Researcher Group

Research output: Contribution to conference › Poster

Abstract

Deep eutectic solvents (DESs) have emerged as an innovative, unique, and exciting class of liquid media that could replace traditional organic solvents. Due to physicochemical interactions that produce less-than-ideal behavior in the liquid phase, these solvents have far lower melting temperatures than their pure compounds. DESs comprise hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs), where the physicochemical properties of DESs can be tailored by selecting combinations of distinct HBAs and HBDs.
The aim of this study was to find the eutectic point of DES obtained by choline chloride (HBA) and sorbitol or isomalt as HBDs; predict the solubility of ibuprofen in them using in silico model of COSMO-RS.

Original language	English
Pages	112
Number of pages	1
DOIs	https://doi.org/10.13140/RG.2.2.29113.84323
Publication status	Published - 11 Oct 2025
Event	The 24th biennial conference EcoBalt2025: Green and sustainable chemistry - Vilnius, Lithuania, Vilnius, Lithuania Duration: 8 Oct 2025 → 10 Nov 2025 https://ecobalt.ftmc.lt/conference-details/#About-EcoBalt2025

Conference

Conference	The 24th biennial conference EcoBalt2025
Country/Territory	Lithuania
City	Vilnius
Period	8/10/25 → 10/11/25
Internet address	https://ecobalt.ftmc.lt/conference-details/#About-EcoBalt2025

Keywords*

Eutectic solvents
poorly soluble drugs
green chemistry
ibuprofen

Field of Science*

1.4 Chemical sciences
3.1 Basic medicine

Publication Type*

3.4. Other publications in conference proceedings (including local)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.13140/RG.2.2.29113.84323

Cite this

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title = "Preparation of eco-friendly eutectic solvents to improve the solubility of drugs",

abstract = "Deep eutectic solvents (DESs) have emerged as an innovative, unique, and exciting class of liquid media that could replace traditional organic solvents. Due to physicochemical interactions that produce less-than-ideal behavior in the liquid phase, these solvents have far lower melting temperatures than their pure compounds. DESs comprise hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs), where the physicochemical properties of DESs can be tailored by selecting combinations of distinct HBAs and HBDs. The aim of this study was to find the eutectic point of DES obtained by choline chloride (HBA) and sorbitol or isomalt as HBDs; predict the solubility of ibuprofen in them using in silico model of COSMO-RS.",

keywords = "Eutectic solvents, poorly soluble drugs, green chemistry, ibuprofen",

author = "Katarīna Gurkina and Rihards Mahinovs and Līga Pētersone and Valentyn Mohylyuk",

year = "2025",

month = oct,

day = "11",

doi = "10.13140/RG.2.2.29113.84323",

language = "English",

pages = "112",

note = "The 24th biennial conference EcoBalt2025 : Green and sustainable chemistry ; Conference date: 08-10-2025 Through 10-11-2025",

url = "https://ecobalt.ftmc.lt/conference-details/\#About-EcoBalt2025",

}

TY - CONF

T1 - Preparation of eco-friendly eutectic solvents to improve the solubility of drugs

AU - Gurkina, Katarīna

AU - Mahinovs, Rihards

AU - Pētersone, Līga

AU - Mohylyuk, Valentyn

PY - 2025/10/11

Y1 - 2025/10/11

N2 - Deep eutectic solvents (DESs) have emerged as an innovative, unique, and exciting class of liquid media that could replace traditional organic solvents. Due to physicochemical interactions that produce less-than-ideal behavior in the liquid phase, these solvents have far lower melting temperatures than their pure compounds. DESs comprise hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs), where the physicochemical properties of DESs can be tailored by selecting combinations of distinct HBAs and HBDs. The aim of this study was to find the eutectic point of DES obtained by choline chloride (HBA) and sorbitol or isomalt as HBDs; predict the solubility of ibuprofen in them using in silico model of COSMO-RS.

AB - Deep eutectic solvents (DESs) have emerged as an innovative, unique, and exciting class of liquid media that could replace traditional organic solvents. Due to physicochemical interactions that produce less-than-ideal behavior in the liquid phase, these solvents have far lower melting temperatures than their pure compounds. DESs comprise hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs), where the physicochemical properties of DESs can be tailored by selecting combinations of distinct HBAs and HBDs. The aim of this study was to find the eutectic point of DES obtained by choline chloride (HBA) and sorbitol or isomalt as HBDs; predict the solubility of ibuprofen in them using in silico model of COSMO-RS.

KW - Eutectic solvents

KW - poorly soluble drugs

KW - green chemistry

KW - ibuprofen

UR - https://ecobalt.ftmc.lt/wp-content/uploads/2025/10/EcoBalt2025_Book_of_Abstracts_V1-cor1_2025-10-24.pdf

U2 - 10.13140/RG.2.2.29113.84323

DO - 10.13140/RG.2.2.29113.84323

M3 - Poster

SP - 112

T2 - The 24th biennial conference EcoBalt2025

Y2 - 8 October 2025 through 10 November 2025

ER -

Preparation of eco-friendly eutectic solvents to improve the solubility of drugs

Abstract

Conference

Keywords*

Field of Science*

Publication Type*

UN SDGs

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Deep eutectic solvents: An innovative green approach for Solubility enhancement of poorly water-soluble drugs

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Preparation of eco-friendly eutectic solvents to improve the solubility of drugs

Abstract

Conference

Keywords*

Field of Science*

Publication Type*

UN SDGs

Access to Document

Other files and links

Fingerprint

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Deep eutectic solvents: An innovative green approach for Solubility enhancement of poorly water-soluble drugs

Cite this