Presence of Human Bocavirus 1 in Hospitalised Children with Acute Respiratory Tract Infections in Latvia and Lithuania

Zaiga Nora-Krūkle, Santa Rasa, Anda Vilmane, Sabīne Grāvelsiņa, Mārtiņš Kālis, Inga Ziemele, Milda Naciute, Sigita Petraitiene, Diana Mieliauskaite, Migle Klimantaviciene, Irute Girkontaite, Hsin Fu Liu, Jih Hui Lin, Yung Cheng Lin, Hsiu Chuan Chan, Dace Gardovska, Modra Murovska

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Human bocavirus 1 (HBoV1) is a parvovirus recently found to be a possible aetiologic agent of acute respiratory disease in children. We conducted the first clinical and molecular study on this virus in Latvia (LV) and Lithuania (LT). The aim of the study was to determine the occurrence of HBoV1 in respiratory tract samples taken from hospitalised children with acute respiratory tract infections in LV and LT. In total 186 children with age one to 50 months, and who fulfilled criteria of acute respiratory tract infection, including lower respiratory tract infections, with or without fever, were included in this study. A nasopharyngeal aspirate was obtained from each patient on admission. DNA was isolated and polimerase chain reaction (PCR) performed targeting the HBoV1 NS1sequence. HBoV1 positive samples were sequenced and phylogenetic analysis was performed. HBoV1 sequence was detected in 42 (32%) of 130 LV and in 8 (14%) of 56 LT samples. In LV the majority of patients with HBoV1 infection were observed in February while in LT in October. The phylogenetic tree for HBoV1 indicated that isolates of HBoV1 cluster closely and include almost all of the isolates in this study. HBoV1 is common in Latvia and Lithuania and might be a significant pathogen that contributes to acute respiratory tract infections in children.

Original languageEnglish
Pages (from-to)198-204
Number of pages7
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume70
Issue number4
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • BoV1
  • phylogenetic analysis
  • respiratory tract infections

Field of Science

  • 3.3 Health sciences
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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