TY - JOUR
T1 - Prostate cancer trends in Latvia during 1990-2012
T2 - Incidence, prevalence, mortality, and survival rates
AU - Plonis, Juris
AU - Bokums, Kristaps
AU - Cauce, Vinita
AU - Miklasevics, Edvins
AU - Vaganovs, Peteris
AU - Irmejs, Arvids
AU - Gardovskis, Janis
AU - Vjaters, Egils
N1 - Funding Information:
This study was supported by the Latvian Urological Association and the National Research Programmes of the Latvian Republic Ministry of Education and Science.
Publisher Copyright:
© 2014 Lithuanian University of Health Sciences.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - Background and objective: Prostate cancer (PCa) is one of the most common form of cancer in males worldwide. One of the highest PCa-related mortality rates in the world is observed in Latvia. Materials and methods: Our study included male patients diagnosed with PCa between 1990 and 2012. We analyzed incidence, prevalence and mortality trends using joinpoint analysis. Kaplan-Meier analysis was performed for 5-, 10-, 15- and 20-year overall survival and cancer-specific survival rates. Results: A total of 14,083 PCa patients with a mean age of initial PCa diagnosis being 70.1 (SD 8.6) was registered. The standardized incidence rates (per 100,000) increased from 18.9 in 1990 to 74.7 in 2012, while the standardized prevalence rates (per 100,000) increased from 69.9 in 1990 to 437.6 in 2012. Standardized PCa mortality rates (per 100,000) also rose from 13.2 in 1990 to 27.2 in 2006 followed by statistically insignificant decrease continuing up to 2012. The mean 5-year cancer-specific survival rates increased from 43.6% in 1990 to 70.7% in 2007, and the mean 10-year cancer-specific survival rates from 32.9% in 1990 to 40.5% in 2001. Conclusions: This study revealed that the incidence, prevalence and mortality rates increased between 1990 and 2012, and although the 5- and 10-year overall and cancer-specific survival rates improved over the reviewed period they still needed to get better.
AB - Background and objective: Prostate cancer (PCa) is one of the most common form of cancer in males worldwide. One of the highest PCa-related mortality rates in the world is observed in Latvia. Materials and methods: Our study included male patients diagnosed with PCa between 1990 and 2012. We analyzed incidence, prevalence and mortality trends using joinpoint analysis. Kaplan-Meier analysis was performed for 5-, 10-, 15- and 20-year overall survival and cancer-specific survival rates. Results: A total of 14,083 PCa patients with a mean age of initial PCa diagnosis being 70.1 (SD 8.6) was registered. The standardized incidence rates (per 100,000) increased from 18.9 in 1990 to 74.7 in 2012, while the standardized prevalence rates (per 100,000) increased from 69.9 in 1990 to 437.6 in 2012. Standardized PCa mortality rates (per 100,000) also rose from 13.2 in 1990 to 27.2 in 2006 followed by statistically insignificant decrease continuing up to 2012. The mean 5-year cancer-specific survival rates increased from 43.6% in 1990 to 70.7% in 2007, and the mean 10-year cancer-specific survival rates from 32.9% in 1990 to 40.5% in 2001. Conclusions: This study revealed that the incidence, prevalence and mortality rates increased between 1990 and 2012, and although the 5- and 10-year overall and cancer-specific survival rates improved over the reviewed period they still needed to get better.
KW - Epidemiology
KW - Prostate cancer
KW - Prostate cancer treatment
KW - Survival rates
UR - http://www.scopus.com/inward/record.url?scp=84923775717&partnerID=8YFLogxK
U2 - 10.1016/j.medici.2014.11.002
DO - 10.1016/j.medici.2014.11.002
M3 - Article
C2 - 25541262
AN - SCOPUS:84923775717
SN - 1010-660X
VL - 50
SP - 313
EP - 317
JO - Medicina (Lithuania)
JF - Medicina (Lithuania)
IS - 6
ER -
