Protective reactivity and alteration of the brain tissue in alcoholics evidenced by sod1, mmp9 immunohistochemistry, and electron microscopy

Sandra Skuja, Valerija Groma, Kristine Ravina, Mihails Tarasovs, Vinita Cauce, Ojars Teteris

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Alcohol and its associated oxidative stress is one of the widespread contributors to the brain damage. Matrix metalloproteinases, which are extensively analyzed in brain pathology studies, are not sufficiently investigated in chronic alcohol consumption. This study evaluated regional brain damage caused by oxidative stress. Contribution of metalloproteinase-9 to this affection was evidenced in alcoholic subjects and correlated with ultrastructural changes. The authors found correlation between neuronal expression patterns of superoxide dismutase-1 and metalloproteinase-9 in nigral (r=0.532, p<0.001), striatal (r=0.327, p<0.001), and cortical (r=0.306, p<0.001) regions, and a significant decrease of nigral superoxide dismutase-1 median values accompanied by severe myelin damage.

Original languageEnglish
Pages (from-to)346-355
Number of pages10
JournalUltrastructural Pathology
Volume37
Issue number5
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Alcohol
  • Matrix metalloproteinases
  • Myelin
  • Oxidative stress

Field of Science

  • 3.1 Basic medicine
  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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