Abstract
Alcohol and its associated oxidative stress is one of the widespread contributors to the brain damage. Matrix metalloproteinases, which are extensively analyzed in brain pathology studies, are not sufficiently investigated in chronic alcohol consumption. This study evaluated regional brain damage caused by oxidative stress. Contribution of metalloproteinase-9 to this affection was evidenced in alcoholic subjects and correlated with ultrastructural changes. The authors found correlation between neuronal expression patterns of superoxide dismutase-1 and metalloproteinase-9 in nigral (r=0.532, p<0.001), striatal (r=0.327, p<0.001), and cortical (r=0.306, p<0.001) regions, and a significant decrease of nigral superoxide dismutase-1 median values accompanied by severe myelin damage.
Original language | English |
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Pages (from-to) | 346-355 |
Number of pages | 10 |
Journal | Ultrastructural Pathology |
Volume | 37 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 2013 |
Keywords*
- Alcohol
- Matrix metalloproteinases
- Myelin
- Oxidative stress
Field of Science*
- 3.1 Basic medicine
- 1.6 Biological sciences
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database