TY - JOUR
T1 - Quantitative multispectral imaging differentiates melanoma from seborrheic keratosis
AU - Bozsányi, Szabolcs
AU - Farkas, Klára
AU - Bánvölgyi, András
AU - Lőrincz, Kende
AU - Fésűs, Luca
AU - Anker, Pálma
AU - Zakariás, Sára
AU - Jobbágy, Antal
AU - Lihacova, Ilze
AU - Lihachev, Alexey
AU - Lange, Marta
AU - Bliznuks, Dmitrijs
AU - Medvecz, Márta
AU - Kiss, Norbert
AU - Wikonkál, Norbert M.
N1 - Funding Information:
This work was supported by grants from the EFOP-3.6.3-VEKOP-16-2017-00009 (S.B., P.A.) EFOP-3.6.3-VEKOP-16 (S.B.) the ÚNKP-20-4-II-SE-7 (N.K.) and ÚNKP-20-3-I-SE-24 (S.Z.) New National Excellence Program of the Ministry For Innovation and Technology from the source of the National Research, Development and Innovation Fund of Hungary and the European Regional Development Fund projects “Time-resolved autofluorescence methodology for non-invasive skin cancer diagnostics” [No. 1.1.1.2/16/I/001, agreement No. 1.1.1.2/VIAA/1/16/014 (A.L.)] and “Development and clinical validation of a novel cost effective multi-modal methodology for early diagnostics of skin cancers” [No. 1.1.1.2/16/I/001 agreement No. 1.1.1.2/VIAA/1/16/052 (I.L.)] and the National Research, Development and Innovation Office of Hungary—NKFIH (FK_131916, 2019 (Semmelweis University, M.M.)).
Publisher Copyright:
© 2021 by the authors.
PY - 2021/8
Y1 - 2021/8
N2 - Melanoma is a melanocytic tumor that is responsible for the most skin cancer-related deaths. By contrast, seborrheic keratosis (SK) is a very common benign lesion with a clinical picture that may resemble melanoma. We used a multispectral imaging device to distinguish these two entities, with the use of autofluorescence imaging with 405 nm and diffuse reflectance imaging with 525 and 660 narrow-band LED illumination. We analyzed intensity descriptors of the acquired images. These included ratios of intensity values of different channels, standard deviation and minimum/maximum values of intensity of the lesions. The pattern of the lesions was also assessed with the use of particle analysis. We found significantly higher intensity values in SKs compared with melanoma, especially with the use of the autofluorescence channel. Moreover, we found a significantly higher number of particles with high fluorescence in SKs. We created a parameter, the SK index, using these values to differentiate melanoma from SK with a sensitivity of 91.9% and specificity of 57.0%. In conclusion, this imaging technique is potentially applicable to distinguish melanoma from SK based on the analysis of various quantitative parameters. For this application, multispectral imaging could be used as a screening tool by general physicians and non-experts in the everyday practice.
AB - Melanoma is a melanocytic tumor that is responsible for the most skin cancer-related deaths. By contrast, seborrheic keratosis (SK) is a very common benign lesion with a clinical picture that may resemble melanoma. We used a multispectral imaging device to distinguish these two entities, with the use of autofluorescence imaging with 405 nm and diffuse reflectance imaging with 525 and 660 narrow-band LED illumination. We analyzed intensity descriptors of the acquired images. These included ratios of intensity values of different channels, standard deviation and minimum/maximum values of intensity of the lesions. The pattern of the lesions was also assessed with the use of particle analysis. We found significantly higher intensity values in SKs compared with melanoma, especially with the use of the autofluorescence channel. Moreover, we found a significantly higher number of particles with high fluorescence in SKs. We created a parameter, the SK index, using these values to differentiate melanoma from SK with a sensitivity of 91.9% and specificity of 57.0%. In conclusion, this imaging technique is potentially applicable to distinguish melanoma from SK based on the analysis of various quantitative parameters. For this application, multispectral imaging could be used as a screening tool by general physicians and non-experts in the everyday practice.
KW - Autofluorescence imaging
KW - Dermoscopy
KW - Diagnosis
KW - Diffuse reflectance imaging
KW - LED
KW - Melanoma
KW - Quantitative analysis
KW - Seborrheic keratosis
UR - http://www.scopus.com/inward/record.url?scp=85111968132&partnerID=8YFLogxK
U2 - 10.3390/diagnostics11081315
DO - 10.3390/diagnostics11081315
M3 - Article
AN - SCOPUS:85111968132
SN - 2075-4418
VL - 11
JO - Diagnostics
JF - Diagnostics
IS - 8
M1 - 1315
ER -
