Quantitative multispectral imaging differentiates melanoma from seborrheic keratosis

Szabolcs Bozsányi, Klára Farkas, András Bánvölgyi, Kende Lőrincz, Luca Fésűs, Pálma Anker, Sára Zakariás, Antal Jobbágy, Ilze Lihacova, Alexey Lihachev, Marta Lange, Dmitrijs Bliznuks, Márta Medvecz, Norbert Kiss (Coresponding Author), Norbert M. Wikonkál

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Melanoma is a melanocytic tumor that is responsible for the most skin cancer-related deaths. By contrast, seborrheic keratosis (SK) is a very common benign lesion with a clinical picture that may resemble melanoma. We used a multispectral imaging device to distinguish these two entities, with the use of autofluorescence imaging with 405 nm and diffuse reflectance imaging with 525 and 660 narrow-band LED illumination. We analyzed intensity descriptors of the acquired images. These included ratios of intensity values of different channels, standard deviation and minimum/maximum values of intensity of the lesions. The pattern of the lesions was also assessed with the use of particle analysis. We found significantly higher intensity values in SKs compared with melanoma, especially with the use of the autofluorescence channel. Moreover, we found a significantly higher number of particles with high fluorescence in SKs. We created a parameter, the SK index, using these values to differentiate melanoma from SK with a sensitivity of 91.9% and specificity of 57.0%. In conclusion, this imaging technique is potentially applicable to distinguish melanoma from SK based on the analysis of various quantitative parameters. For this application, multispectral imaging could be used as a screening tool by general physicians and non-experts in the everyday practice.

Original languageEnglish
Article number1315
Issue number8
Publication statusPublished - Aug 2021
Externally publishedYes


  • Autofluorescence imaging
  • Dermoscopy
  • Diagnosis
  • Diffuse reflectance imaging
  • LED
  • Melanoma
  • Quantitative analysis
  • Seborrheic keratosis

Field of Science*

  • 1.3 Physical sciences
  • 1.4 Chemical sciences
  • 1.6 Biological sciences
  • 2.6 Medical engineering

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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