Reactogenicity of synthetic hydroxyapatite (HAp) ceramic materials implanted in rabbits jaws

I. Salma, Mara Pilmane, J. Vetra, L. Berzina-Cimdina, G. Salms, A. Skagers

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Experimental comparing of morphofunctional changes in implant contact tissue with same tissue involved in surgical intervention of same manner without insertion of artificial materials can clarify specific reactogenicity of implant and/or material. To evaluate early reactogenicity of porous synthetic HAp ceramic implants inserted in holes of rabbit upper jaw assessment of inflammatory response and regeneration in contact bone and soft tissue using histological and immunohistochemical methods was done. Our results demonstrated stimulation of TGFβ and FGFR1 in bone after HAp implantation indicating possible osseoinductive role for the same Hap implants. Also moderate apoptosis and rich expression of FGFR1 in connective tissue around HAp implants commonly indicated intensive regeneration ability of the soft tissue with such cell death type that does not cause the fibrotic changes. Neuropeptide-containing innervation was not involved in healing processes after HAp implantation.

Original languageEnglish
Title of host publication14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008
PublisherSpringer Verlag
Number of pages4
ISBN (Print)9783540693666
Publication statusPublished - 2008

Publication series

NameIFMBE Proceedings
Volume20 IFMBE
ISSN (Print)1680-0737


  • apoptosis
  • growth factors
  • hydroxyapatite ceramic
  • reactogenicity

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine
  • 2.6 Medical engineering

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database


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