Experimental comparing of morphofunctional changes in implant contact tissue with same tissue involved in surgical intervention of same manner without insertion of artificial materials can clarify specific reactogenicity of implant and/or material. To evaluate early reactogenicity of porous synthetic HAp ceramic implants inserted in holes of rabbit upper jaw assessment of inflammatory response and regeneration in contact bone and soft tissue using histological and immunohistochemical methods was done. Our results demonstrated stimulation of TGFβ and FGFR1 in bone after HAp implantation indicating possible osseoinductive role for the same Hap implants. Also moderate apoptosis and rich expression of FGFR1 in connective tissue around HAp implants commonly indicated intensive regeneration ability of the soft tissue with such cell death type that does not cause the fibrotic changes. Neuropeptide-containing innervation was not involved in healing processes after HAp implantation.