Relapsed ocular squamous surface neoplasia treated with topical interferon alfa-2b

Carlos Rocha-de-Lossada, Carmen Alba-Linero, Davide Barroni, Rahul Rachwani-Anil, Francisco Zamorano-Martín, Marina Rodríguez-Calvo-de-Mora

Research output: Contribution to journalArticlepeer-review


A 54-year-old patient presented with a large, fleshy conjunctival lesion in the right eye that had been previously surgically removed in another centre. Diagnosis of Conjunctival intraepithelial neoplasia (CIN) was confirmed by conjunctival impression cytology. The tumor was treated with topical IFN-α-2β (1,000,000 IU/ (ml) adjuvant to surgery for chemoreduction purposes. One month after treatment, the lesion showed almost complete involution, therefore the treatment was continued up to 6 months, and the lesion showed full regression. The patient is currently under periodical follow-up by conjunctival impression cytology. We consider that topical IFN-α-2β can be used in CIN for chemoreduction and/ or curative purposes. We believe that conjunctival impression cytology is a useful and non-invasive method for diagnosis and follow-up in this condition.

Original languageEnglish
Pages (from-to)62-65
Number of pages4
JournalRomanian journal of ophthalmology
Issue number1
Publication statusPublished - 16 Apr 2020


  • conjunctival intraepithelial neoplasia
  • ocular squamous surface neoplasia
  • limbal neoplasia
  • epidermoid carcinoma
  • impression cytology
  • Interferon α-2β

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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