Relationship between changes in omentin and chemerin levels and metabolic indices of obesity within one year in non-morbid overweight and obese adults

Vija Siliņa (Coresponding Author), Mesfin K. Tessma, Jeļena Daniļenko, Silva Seņkāne, Guntis Bahs

Research output: Contribution to journalMeeting Abstractpeer-review


We used data from our randomised controlled study with 123 clinically healthy individuals with a BMI above 25 m2/kg in the age group of 30 to 45. All participants received a consultation for lifestyle changes to support weight loss. All group showed slight weight and waist circumference decrease after 1 year. Biochemical parameters (lipids, fasting glucose, insulin) and cytokines (omentin, chemerin) were assessed at baseline and after 1 year.
We found correlation between changes in chemerin and insulin (rs=0.21; p=0.019). There was a positive correlation of TG/HDL-C ratio changes with chemerin changes (rs=0.18; p=0.047) and negative with omentin
changes (rs=-0.21; p=0.018). Multiple linear regression revealed significant relationship in chemerin changes when insulin (B=0.6; 95%CI 0.1, 1.0; p=0.016) or TG/HDL-C ratio (B=3.6; 95%CI 0.3, 7.0; p=0.035) differences are included in the model while controlling for age and gender. For omentin changes only gender stayed as predictor of weight (B=22.8; 95%CI 7.3, 38.0; p=0.004), insulin
(B=23.1; 95%CI 7.7, 38.4; p=0.004) and TG/HDL-C ratio (B=23.1; 95%CI 7.9, 38.2; p=0.003) changes, when adjusted by age.
Overweight is a condition that could lead to both diabetes and cardiovascular diseases. About half of EU adult population is owerweight, including 16% being obese (21% in Latvia). Correlation of serum chemerin and omentin with indices of insulin resistance and lipids has been described, however, information on association between changes in these parameters is scarce.
Results imply that chemerin changes are associated with changes in insulin and some lipids. Male gender rather than changes insulin and lipids is associated with omentin changes.
Research questions:
To examine relationship between changes in chemerin and omentin levels with changes of insulin resistance and lipid levels in clinically healthy overweight and obese individuals within a year.
Points for discussion:
The role of chemerin and omentin in early selection and monitoring overweight individuals to prevent diabetes and cardiovascular disease is still ambiguous
Presentation on 11/05/2019 14:00 in "Poster Session 2 - Diabetes" by Vija Silina.
Original languageEnglish
Pages (from-to)22
Number of pages1
JournalEurasian Journal of Family Medicine
Issue numberSuppl.2
Publication statusPublished - 2019
Event88th European General Practice Research Network (EGPRN) Meeting: Research on Multimorbidity in Primary Care - University of Tampere, Tampere, Finland
Duration: 9 May 201912 May 2019
Conference number: 88


  • omentin
  • Chemerin
  • Overweight
  • Obesity

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)


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