Abstract
Method:
We used data from our randomised controlled study with 123 clinically healthy individuals with a BMI above 25 m2/kg in the age group of 30 to 45. All participants received a consultation for lifestyle changes to support weight loss. All group showed slight weight and waist circumference decrease after 1 year. Biochemical parameters (lipids, fasting glucose, insulin) and cytokines (omentin, chemerin) were assessed at baseline and after 1 year.
Results:
We found correlation between changes in chemerin and insulin (rs=0.21; p=0.019). There was a positive correlation of TG/HDL-C ratio changes with chemerin changes (rs=0.18; p=0.047) and negative with omentin
changes (rs=-0.21; p=0.018). Multiple linear regression revealed significant relationship in chemerin changes when insulin (B=0.6; 95%CI 0.1, 1.0; p=0.016) or TG/HDL-C ratio (B=3.6; 95%CI 0.3, 7.0; p=0.035) differences are included in the model while controlling for age and gender. For omentin changes only gender stayed as predictor of weight (B=22.8; 95%CI 7.3, 38.0; p=0.004), insulin
(B=23.1; 95%CI 7.7, 38.4; p=0.004) and TG/HDL-C ratio (B=23.1; 95%CI 7.9, 38.2; p=0.003) changes, when adjusted by age.
Background:
Overweight is a condition that could lead to both diabetes and cardiovascular diseases. About half of EU adult population is owerweight, including 16% being obese (21% in Latvia). Correlation of serum chemerin and omentin with indices of insulin resistance and lipids has been described, however, information on association between changes in these parameters is scarce.
Conclusions:
Results imply that chemerin changes are associated with changes in insulin and some lipids. Male gender rather than changes insulin and lipids is associated with omentin changes.
Research questions:
To examine relationship between changes in chemerin and omentin levels with changes of insulin resistance and lipid levels in clinically healthy overweight and obese individuals within a year.
Points for discussion:
The role of chemerin and omentin in early selection and monitoring overweight individuals to prevent diabetes and cardiovascular disease is still ambiguous
Presentation on 11/05/2019 14:00 in "Poster Session 2 - Diabetes" by Vija Silina.
We used data from our randomised controlled study with 123 clinically healthy individuals with a BMI above 25 m2/kg in the age group of 30 to 45. All participants received a consultation for lifestyle changes to support weight loss. All group showed slight weight and waist circumference decrease after 1 year. Biochemical parameters (lipids, fasting glucose, insulin) and cytokines (omentin, chemerin) were assessed at baseline and after 1 year.
Results:
We found correlation between changes in chemerin and insulin (rs=0.21; p=0.019). There was a positive correlation of TG/HDL-C ratio changes with chemerin changes (rs=0.18; p=0.047) and negative with omentin
changes (rs=-0.21; p=0.018). Multiple linear regression revealed significant relationship in chemerin changes when insulin (B=0.6; 95%CI 0.1, 1.0; p=0.016) or TG/HDL-C ratio (B=3.6; 95%CI 0.3, 7.0; p=0.035) differences are included in the model while controlling for age and gender. For omentin changes only gender stayed as predictor of weight (B=22.8; 95%CI 7.3, 38.0; p=0.004), insulin
(B=23.1; 95%CI 7.7, 38.4; p=0.004) and TG/HDL-C ratio (B=23.1; 95%CI 7.9, 38.2; p=0.003) changes, when adjusted by age.
Background:
Overweight is a condition that could lead to both diabetes and cardiovascular diseases. About half of EU adult population is owerweight, including 16% being obese (21% in Latvia). Correlation of serum chemerin and omentin with indices of insulin resistance and lipids has been described, however, information on association between changes in these parameters is scarce.
Conclusions:
Results imply that chemerin changes are associated with changes in insulin and some lipids. Male gender rather than changes insulin and lipids is associated with omentin changes.
Research questions:
To examine relationship between changes in chemerin and omentin levels with changes of insulin resistance and lipid levels in clinically healthy overweight and obese individuals within a year.
Points for discussion:
The role of chemerin and omentin in early selection and monitoring overweight individuals to prevent diabetes and cardiovascular disease is still ambiguous
Presentation on 11/05/2019 14:00 in "Poster Session 2 - Diabetes" by Vija Silina.
| Original language | English |
|---|---|
| Pages (from-to) | 22 |
| Number of pages | 1 |
| Journal | Eurasian Journal of Family Medicine |
| Volume | 8 |
| Issue number | Suppl.2 |
| Publication status | Published - 2019 |
| Event | 88th European General Practice Research Network (EGPRN) Meeting: Research on Multimorbidity in Primary Care - University of Tampere, Tampere, Finland Duration: 9 May 2019 → 12 May 2019 Conference number: 88 https://www.woncaeurope.org/m/events/view/88th-egprn-meeting https://www.egprn.org/file/e7db36b0-f56e-4324-b9e1-3b48898daf33/Programme-Book-of-the-88th-EGPRN-Meeting-Tampere-Finland-9-12-May-2019.pdf |
Keywords*
- omentin
- Chemerin
- Overweight
- Obesity
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)
