Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data

Anna Jana Saulīte; Anna Popova; Renārs Erts; Kārlis Rācenis; Linda Kučāne; Aivars Pētersons; Arvydas Laurinavičius; Harijs Čerņevskis; Viktorija Kuzema

doi:10.2478/prolas-2021-0055

Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data

Anna Jana Saulīte (Corresponding Author), Anna Popova, Renārs Erts, Kārlis Rācenis, Linda Kučāne, Aivars Pētersons, Arvydas Laurinavičius, Harijs Čerņevskis, Viktorija Kuzema

Faculty of Medicine

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Abstract

The aim of the study was to determine kidney survival and validate the novel international immunoglobulin A nephropathy (IgAN) prediction tool (PT) in the Latvian population. Adults with morphologically confirmed IgAN were included. Kidney survival was analysed with the Kaplan–Meier method. PT-assigned risk was compared with calculated risk by the Cox regression model. The
Kaplan–Meier analysis included 95 patients. The five-year kidney survival Q3 was 24 months. Women had longer median kidney-survival time (> 60 months) than men (58 months). Median kidney survival in participants with MEST T0 was longer than 60 months; T1 and T2 were 40 and 18 months, respectively. Median kidney survival in participants with diastolic blood pressure (DBP) < 99 mmHg was longer than 60 months, whereas in patients with DBP 100–109 and 110
mmHg, it was 40 and 24 months, respectively. Cox regression analysis included 68 patients. A moderate degree of correlation was found between predicted and observed five-year risk (p = 0.001). Gender, tubular atrophy/interstitial fibrosis, DBP are significant factors affecting kidney survival. Since there was statistically significant correlation and reliability between PT and follow-up analysis data, we conclude that PT could be applied for use in the Latvian population

Original language	English
Pages (from-to)	379-386
Number of pages	8
Journal	Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
Volume	75
Issue number	5
DOIs	https://doi.org/10.2478/prolas-2021-0055
Publication status	Published - Oct 2021

Keywords*

end-stage kidney disease
immunoglobulin A nephropathy
kidney survival risk factors
novel IgAN prediction tool

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.2478/prolas-2021-0055Licence: CC BY-NC-ND

prolas-2021-0055Final published version, 1.6 MBLicence: CC BY-NC-ND

Cite this

Saulīte, A. J., Popova, A., Erts, R., Rācenis, K., Kučāne, L., Pētersons, A., Laurinavičius, A., Čerņevskis, H., & Kuzema, V. (2021). Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data. Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., 75(5), 379-386. https://doi.org/10.2478/prolas-2021-0055

@article{f6788ddfb4ec41a7b31eeaf453d3ae86,

title = "Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data",

abstract = "The aim of the study was to determine kidney survival and validate the novel international immunoglobulin A nephropathy (IgAN) prediction tool (PT) in the Latvian population. Adults with morphologically confirmed IgAN were included. Kidney survival was analysed with the Kaplan–Meier method. PT-assigned risk was compared with calculated risk by the Cox regression model. TheKaplan–Meier analysis included 95 patients. The five-year kidney survival Q3 was 24 months. Women had longer median kidney-survival time (> 60 months) than men (58 months). Median kidney survival in participants with MEST T0 was longer than 60 months; T1 and T2 were 40 and 18 months, respectively. Median kidney survival in participants with diastolic blood pressure (DBP) < 99 mmHg was longer than 60 months, whereas in patients with DBP 100–109 and 110mmHg, it was 40 and 24 months, respectively. Cox regression analysis included 68 patients. A moderate degree of correlation was found between predicted and observed five-year risk (p = 0.001). Gender, tubular atrophy/interstitial fibrosis, DBP are significant factors affecting kidney survival. Since there was statistically significant correlation and reliability between PT and follow-up analysis data, we conclude that PT could be applied for use in the Latvian population",

keywords = "end-stage kidney disease, immunoglobulin A nephropathy, kidney survival risk factors, novel IgAN prediction tool",

author = "Saulīte, {Anna Jana} and Anna Popova and Renārs Erts and Kārlis Rācenis and Linda Ku{\v c}āne and Aivars Pētersons and Arvydas Laurinavi{\v c}ius and Harijs {\v C}erņevskis and Viktorija Kuzema",

note = "Affiliations in Web of Science publication are different from those provided in Scopus database and the original journal publication. Here are given the affiliations from Scopus/original publication in {"}Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences{"}.",

year = "2021",

month = oct,

doi = "10.2478/prolas-2021-0055",

language = "English",

volume = "75",

pages = "379--386",

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Saulīte, AJ, Popova, A, Erts, R, Rācenis, K, Kučāne, L, Pētersons, A, Laurinavičius, A, Čerņevskis, H & Kuzema, V 2021, 'Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data', Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., vol. 75, no. 5, pp. 379-386. https://doi.org/10.2478/prolas-2021-0055

Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data. / Saulīte, Anna Jana (Corresponding Author); Popova, Anna; Erts, Renārs et al.
In: Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., Vol. 75, No. 5, 10.2021, p. 379-386.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data

AU - Saulīte, Anna Jana

AU - Popova, Anna

AU - Erts, Renārs

AU - Rācenis, Kārlis

AU - Kučāne, Linda

AU - Pētersons, Aivars

AU - Laurinavičius, Arvydas

AU - Čerņevskis, Harijs

AU - Kuzema, Viktorija

N1 - Affiliations in Web of Science publication are different from those provided in Scopus database and the original journal publication. Here are given the affiliations from Scopus/original publication in "Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences".

PY - 2021/10

Y1 - 2021/10

N2 - The aim of the study was to determine kidney survival and validate the novel international immunoglobulin A nephropathy (IgAN) prediction tool (PT) in the Latvian population. Adults with morphologically confirmed IgAN were included. Kidney survival was analysed with the Kaplan–Meier method. PT-assigned risk was compared with calculated risk by the Cox regression model. TheKaplan–Meier analysis included 95 patients. The five-year kidney survival Q3 was 24 months. Women had longer median kidney-survival time (> 60 months) than men (58 months). Median kidney survival in participants with MEST T0 was longer than 60 months; T1 and T2 were 40 and 18 months, respectively. Median kidney survival in participants with diastolic blood pressure (DBP) < 99 mmHg was longer than 60 months, whereas in patients with DBP 100–109 and 110mmHg, it was 40 and 24 months, respectively. Cox regression analysis included 68 patients. A moderate degree of correlation was found between predicted and observed five-year risk (p = 0.001). Gender, tubular atrophy/interstitial fibrosis, DBP are significant factors affecting kidney survival. Since there was statistically significant correlation and reliability between PT and follow-up analysis data, we conclude that PT could be applied for use in the Latvian population

AB - The aim of the study was to determine kidney survival and validate the novel international immunoglobulin A nephropathy (IgAN) prediction tool (PT) in the Latvian population. Adults with morphologically confirmed IgAN were included. Kidney survival was analysed with the Kaplan–Meier method. PT-assigned risk was compared with calculated risk by the Cox regression model. TheKaplan–Meier analysis included 95 patients. The five-year kidney survival Q3 was 24 months. Women had longer median kidney-survival time (> 60 months) than men (58 months). Median kidney survival in participants with MEST T0 was longer than 60 months; T1 and T2 were 40 and 18 months, respectively. Median kidney survival in participants with diastolic blood pressure (DBP) < 99 mmHg was longer than 60 months, whereas in patients with DBP 100–109 and 110mmHg, it was 40 and 24 months, respectively. Cox regression analysis included 68 patients. A moderate degree of correlation was found between predicted and observed five-year risk (p = 0.001). Gender, tubular atrophy/interstitial fibrosis, DBP are significant factors affecting kidney survival. Since there was statistically significant correlation and reliability between PT and follow-up analysis data, we conclude that PT could be applied for use in the Latvian population

KW - end-stage kidney disease

KW - immunoglobulin A nephropathy

KW - kidney survival risk factors

KW - novel IgAN prediction tool

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U2 - 10.2478/prolas-2021-0055

DO - 10.2478/prolas-2021-0055

M3 - Article

SN - 2255-890X

VL - 75

SP - 379

EP - 386

JO - Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

JF - Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

IS - 5

ER -

Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data

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