Response of osteoporotic bone to the implantation of biphasic calcium phosphate (BCP) bioceramics

A. Grisulonoks, I. Salma, G. Salms, L. Neimane, A. Skagers, J. Locs

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Osteoporosis is a chronic, metabolic and systemic skeletal disease characterized by low bone mineral density (BMD) and micro-architectural deterioration, resulting in increased bone fragility and fracture risk. Changes in the mineral structure occur due to aging or because of progressive pathologic processes such as osteoporosis, as well as in both aging and effects of bone diseases. Materials and methods. Experimental osteoporosis was induced on twenty 8 months old female rabbits by ovarioectomy and methylprednisolone course daily i/m 6 weeks 1mg/kg. Bone defect was made in femur trochanter major region and filled with 0, 5 mm granules of pure biphasic calcium phosphate (BCP, HAp/TCP 30/70) and TCP granules saturated with Stroncium 5% (Sr). In control groups were 2 healthy rabbits and 4 with experimental osteoporosis without implantation of bioceramics. After 3 months animals were euthanased and samples from different bone parts were taken. Results. Average HU value in rabbits jaw premolar region in control group of healthy animals was 782, 53, statistically significant in comparison with biphasic calcium phosphate group (0,008; (P < 0,05) and with Stroncium group (0,001;(P<.05). HU in jaws of rabbits with experimental osteoporosis without implantation of biomaterials was 677, 75. Average HU value in jaw of group with pure BCP granules in femur was 437, 14, but in group, were granules were saturated with Stroncium was 446, 14. Difference between them was not statistically significant (0, 92; P>.05).

Original languageEnglish
Title of host publicationMaterial and Manufacturing Technology IX
EditorsVladimir Khovaylo, Ghenadii Korotcenkov
PublisherTrans Tech Publications Ltd
Number of pages5
ISBN (Print)9783035713558
Publication statusPublished - 2018
Event9th International Conference on Material and Manufacturing Technology - Moscow, Russian Federation
Duration: 28 Apr 201830 Apr 2018
Conference number: 9

Publication series

NameKey Engineering Materials
Volume780 KEM
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795


Conference9th International Conference on Material and Manufacturing Technology
Abbreviated titleICMMT 2018
Country/TerritoryRussian Federation


  • Bioceramics
  • Bone mineral density
  • Experimental osteoporosis

Field of Science*

  • 2.5 Materials engineering
  • 3.2 Clinical medicine

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database


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