Response of osteoporotic jaw bone to implantation of biphasic calcium phosphate bioceramics supplemented with autologous mesenchymal cells

Aleksandrs Grisulonoks, Inese Cakstina, Arnis Abolins, Janis Locs, Andrejs Skagers, Ilze Salma, Girts Salms, Vadims Klimecs

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

To target areas of the skeletal system which are clinically significant sites is a new strategy as the"local treatment of osteoporosis". Synthetic bioceramics implanted into critical sized bone defect of rats with experimental osteoporosis demonstrateds better effect to bone tissue repair in osteoporosis and/or osteoporosis status. Stem cell transplantation may improve bone mineral density in animal models of osteoporosis. An adequate blood supply of mesenchymal cells (MSCs and osteoprogenitors) is important for efficient bone regeneration. The concentration and quality of MSCs may vary significantly, depending on the individual (especially in older people), the cell obtaining sites and techniques used. Combination of BCP and stem cells are not studied on old experimental animals with double induced osteoporosis.

Original languageEnglish
Title of host publicationEngineering Materials and Tribology XXV
EditorsDagnija Loca
PublisherTrans Tech Publications Ltd
Pages240-244
Number of pages5
ISBN (Print)9783035710724
DOIs
Publication statusPublished - 2017
Event25th International Baltic Conference of Engineering Materials and Tribology – BALTMATTRIB - Riga, Latvia
Duration: 3 Nov 20164 Nov 2016
Conference number: 25

Publication series

NameKey Engineering Materials
Volume721 KEM
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Conference

Conference25th International Baltic Conference of Engineering Materials and Tribology – BALTMATTRIB
Country/TerritoryLatvia
CityRiga
Period3/11/164/11/16

Keywords

  • Biphasic calcium phosphate bioceramics
  • Bone regeneration
  • Experimental osteoporosis
  • Mesenchymal cells

Field of Science

  • 2.5 Materials engineering
  • 2.6 Medical engineering

Publication Type

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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