Risk factor analysis for gout in the Latvian population

Erika Nagle (Coresponding Author), Nellija Luksa, Georgijs Moisejevs, Linda Gailîte

Research output: Contribution to journalArticlepeer-review

Abstract

Gout (Gr. podagra) is a multifactorial pathology, which means that both genetic and environmental factors play a role in the aetiology of the disease. For these reasons, revealing risk factors could be of very high importance in prevention and treatment of gout. In the present study, we found that a major role in gout predisposition is played by specific alleles in the ABCG2 gene. The study used survey data for 43 gout patients and 99 healthy control individuals who were genotyped for rs2231142. It was found that allelic variant rs2231142 in the ABCG2 gene had the strongest association with gout. Among other co-factors studied, sex, and increased body mass index were associated with gout.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume74
Issue number1
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • ABCG2 gene
  • Podagra
  • Q141K
  • Rs2231142

Field of Science

  • 3.1 Basic medicine
  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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