Abstract
BACKGROUND:
Oral lichen planus (OLP) is the most common non-infectious, chronic inflammatory oral disease affecting 1-2% of the general adult population with chronic
potential of transforming into squamous cell carcinoma and therefore it considered to be a precancerous condition. The aetiology of OLP is unclear however viruses have been in spot of investigation. The aim of the study is to provide currently available information on the association of different viruses mainly EBV and HHV-7 in the development OLP.
MATERIALS AND METHODS:
Online databases (PubMed, ProQuest, Scopus, Research gate, Science direct and Google Scholar) were searched from date of inception till November 2021. Studies were included if they met the following criteria: 1) observational studies, 2) the study comprised OLP patients and control subjects, 3) diagnosis of OLP was confirmed histopathologically, and 4) articles were in English.
RESULTS:
A total number of 10 studies (from 27) comprising 403 OLP cases and 216 controls were included for evaluating the role of EBV and HHV-7. The results of the pooled studies revealed a significant positive association between EBV and OLP prevalence being 25.5 % in 5 studies and between HHV-7 and OLP being 33.3% in just 1 study. Studies also showed significant role of other viruses (CMV, HPV, HSV and HCV) in the development of oral lichen planus.
CONCLUSION:
The results suggest that EBV and HHV-7 infection is significantly associated with increased risk of OLP. However, these results are preliminary, and high‐ quality, large‐scale studies are required to further explore the potential role of viruses in the pathogenesis of OLP.
Oral lichen planus (OLP) is the most common non-infectious, chronic inflammatory oral disease affecting 1-2% of the general adult population with chronic
potential of transforming into squamous cell carcinoma and therefore it considered to be a precancerous condition. The aetiology of OLP is unclear however viruses have been in spot of investigation. The aim of the study is to provide currently available information on the association of different viruses mainly EBV and HHV-7 in the development OLP.
MATERIALS AND METHODS:
Online databases (PubMed, ProQuest, Scopus, Research gate, Science direct and Google Scholar) were searched from date of inception till November 2021. Studies were included if they met the following criteria: 1) observational studies, 2) the study comprised OLP patients and control subjects, 3) diagnosis of OLP was confirmed histopathologically, and 4) articles were in English.
RESULTS:
A total number of 10 studies (from 27) comprising 403 OLP cases and 216 controls were included for evaluating the role of EBV and HHV-7. The results of the pooled studies revealed a significant positive association between EBV and OLP prevalence being 25.5 % in 5 studies and between HHV-7 and OLP being 33.3% in just 1 study. Studies also showed significant role of other viruses (CMV, HPV, HSV and HCV) in the development of oral lichen planus.
CONCLUSION:
The results suggest that EBV and HHV-7 infection is significantly associated with increased risk of OLP. However, these results are preliminary, and high‐ quality, large‐scale studies are required to further explore the potential role of viruses in the pathogenesis of OLP.
| Original language | English |
|---|---|
| Pages | 16-17 |
| Number of pages | 2 |
| Publication status | Published - 25 Feb 2022 |
| Event | 1st European Congress on Oral Potentially Malignant Disorders (OPMD): State of the art and a roadmap for research - Brescia, Italy Duration: 25 Feb 2022 → 25 Feb 2022 Conference number: 1 https://oralpremalignant2022.studioprogress.it/ |
Congress
| Congress | 1st European Congress on Oral Potentially Malignant Disorders (OPMD): State of the art and a roadmap for research |
|---|---|
| Abbreviated title | OPMD |
| Country/Territory | Italy |
| City | Brescia |
| Period | 25/02/22 → 25/02/22 |
| Internet address |
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)