Role of ocular angiogenic factors in the development of neovascular age-related macular degeneration

Elīza Briede (Coresponding Author), Kristīne Baumane, Angelika Krūmiņa

Research output: Contribution to journalArticlepeer-review


Age-related macular degeneration (AMD) is a progressive degenerative eye disease. Neovascular age-related macular degeneration (nAMD) is the advanced form of AMD characterised by abnormal growth of newly formed blood vessels in chorioidea which typically involves fluid accumulation in the retina or retinal haemorrhage, retinal epithelial detachments, hard exudate or subretinal scars. The process of angiogenesis is controlled by ocular angiogenic factors, which have enabled the development of different treatment options aimed at these factors. This review aims to compile the available information about the most commonly identified ocular angiogenic factors, uncovering their role in the pathogenesis of nAMD and assessing their application possibilities as biomarkers of disease identification and treatment.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Issue number3
Publication statusPublished - 1 Jun 2020


  • Angiogenic factors
  • Biomarkers
  • Pigment epithelium-derived factor
  • Vascular endothelial growth factor

Field of Science*

  • 3.2 Clinical medicine
  • 3.3 Health sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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