Abstract
Age-related macular degeneration (AMD) is a progressive degenerative eye disease. Neovascular age-related macular degeneration (nAMD) is the advanced form of AMD characterised by abnormal growth of newly formed blood vessels in chorioidea which typically involves fluid accumulation in the retina or retinal haemorrhage, retinal epithelial detachments, hard exudate or subretinal scars. The process of angiogenesis is controlled by ocular angiogenic factors, which have enabled the development of different treatment options aimed at these factors. This review aims to compile the available information about the most commonly identified ocular angiogenic factors, uncovering their role in the pathogenesis of nAMD and assessing their application possibilities as biomarkers of disease identification and treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 159-164 |
| Number of pages | 6 |
| Journal | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences |
| Volume | 74 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Jun 2020 |
Keywords*
- Angiogenic factors
- Biomarkers
- Pigment epithelium-derived factor
- Vascular endothelial growth factor
Field of Science*
- 3.2 Clinical medicine
- 3.3 Health sciences
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database