Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery

A. Skesters (Coresponding Author), D. Kustovs, A. Lece, E. Moreino, E. Petrosina, K. D. Rainsford

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study aimed to assess tendency of oxidative stress in COVID-19 patients depending on severity. Methods: The study was conducted with 80 post-COVID-19 disease patients and 40 acutely ill patients. Content of selenium in blood plasma was detected by a fluorimetric method with di-amino-naphthalene using acidic hydrolysis. Selenoprotein P, malondialdehyde and 4-hydroxynonenal and their metabolite adducts were evaluated by spectrophotometric methods using commercial assay kits. Results: Obtained results showed that selenium content in blood for post-COVID-19 disease patients was of a similar lower norm for Latvian inhabitants. Selenium and seleno-protein P contents for acute patients were significantly decreased compared with post-COVID-19 disease patients. Conclusion: In conclusion, COVID-19 involves induction of antioxidant systems—in case of severe disease, patients have significantly low concentration of selenium, seleno-protein P and higher level of oxidative stress, which, in turn, confirms the more intense formation of free radicals in the body.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalInflammopharmacology
Volume30
Issue number2
DOIs
Publication statusPublished - Apr 2022

Keywords*

  • COVID-19
  • Free radicals
  • Oxidative stress
  • Selenium
  • Selenoprotein P

Field of Science*

  • 3.1 Basic medicine
  • 1.4 Chemical sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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