TY - JOUR
T1 - Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries
AU - Krassas, Gerasimos E.
AU - Pontikides, Nikolaos
AU - Tziomalos, Kostas
AU - Tzotzas, Themistoklis
AU - Zosin, Ioana
AU - Vlad, Mihaela
AU - Luger, Anton
AU - Gessl, Alois
AU - Marculescu, Rodrig
AU - Toscano, Vincenzo
AU - Morgante, Sara
AU - Papini, Enrico
AU - Pirags, Valdis
AU - Konrade, Ilze
AU - Hybsier, Sandra
AU - Hofmann, Peter J.
AU - Schomburg, Lutz
AU - Köhrle, Josef
N1 - Funding Information:
This work was supported partially from U.E.M.S, section of Endocrinology and Metabolism (to GE Krassas) by Deutsche Forschungsgemeinschaft (DFG; SCHO849/4-1) and the German Federal Ministry of Economics and Technology (BMWi; KF2263202CS2) (to L Schomburg). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Publisher Copyright:
© Informa UK, Ltd.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Context: Selenium supplementation has been suggested for Hashimoto thyroiditis and Graves' ophthalmopathy. Objective, Design: Our aim is to measure selenium status (p-Se, p-SePP), urine iodine (UI) levels and urine iodine/creatinine ratio (UI/C) in different thyroid diseases (n = 416) from four European countries and to compare the results between patients with and without thyroid autoimmunity. Results: p-Se and p-SePP showed positive correlation and did not correlate with UI/C. Also, these measurements were higher in patients from Italy in comparison with the other countries. Austria had the lowest UI/C ratios. Selenium deficiency exists in these four European countries. Selenium status was lower in patients with Hashimoto thyroiditis and Graves' disease in comparison with non-autoimmune thyroid disease patients and did not differ between autoimmune patients with or without thyroid peroxidase antibodies. The latter correlated positively with age. Conclusions: Our findings suggest that Se supplementation might have a beneficial effect in autoimmune thyroid patients.
AB - Context: Selenium supplementation has been suggested for Hashimoto thyroiditis and Graves' ophthalmopathy. Objective, Design: Our aim is to measure selenium status (p-Se, p-SePP), urine iodine (UI) levels and urine iodine/creatinine ratio (UI/C) in different thyroid diseases (n = 416) from four European countries and to compare the results between patients with and without thyroid autoimmunity. Results: p-Se and p-SePP showed positive correlation and did not correlate with UI/C. Also, these measurements were higher in patients from Italy in comparison with the other countries. Austria had the lowest UI/C ratios. Selenium deficiency exists in these four European countries. Selenium status was lower in patients with Hashimoto thyroiditis and Graves' disease in comparison with non-autoimmune thyroid disease patients and did not differ between autoimmune patients with or without thyroid peroxidase antibodies. The latter correlated positively with age. Conclusions: Our findings suggest that Se supplementation might have a beneficial effect in autoimmune thyroid patients.
KW - Graves' disease
KW - Hashimoto's thyroiditis
KW - non-autoimmune thyroid disease
KW - plasma selenium
KW - plasma selenoprotein P
KW - selenium status
KW - thyroid diseases
KW - urine iodine
UR - http://www.scopus.com/inward/record.url?scp=84911471336&partnerID=8YFLogxK
U2 - 10.1586/17446651.2014.960845
DO - 10.1586/17446651.2014.960845
M3 - Article
AN - SCOPUS:84911471336
SN - 1744-6651
VL - 9
SP - 685
EP - 692
JO - Expert Review of Endocrinology and Metabolism
JF - Expert Review of Endocrinology and Metabolism
IS - 6
ER -
