Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries

Gerasimos E. Krassas, Nikolaos Pontikides, Kostas Tziomalos, Themistoklis Tzotzas, Ioana Zosin, Mihaela Vlad, Anton Luger, Alois Gessl, Rodrig Marculescu, Vincenzo Toscano, Sara Morgante, Enrico Papini, Valdis Pirags, Ilze Konrade, Sandra Hybsier, Peter J. Hofmann, Lutz Schomburg, Josef Köhrle

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Context: Selenium supplementation has been suggested for Hashimoto thyroiditis and Graves' ophthalmopathy. Objective, Design: Our aim is to measure selenium status (p-Se, p-SePP), urine iodine (UI) levels and urine iodine/creatinine ratio (UI/C) in different thyroid diseases (n = 416) from four European countries and to compare the results between patients with and without thyroid autoimmunity. Results: p-Se and p-SePP showed positive correlation and did not correlate with UI/C. Also, these measurements were higher in patients from Italy in comparison with the other countries. Austria had the lowest UI/C ratios. Selenium deficiency exists in these four European countries. Selenium status was lower in patients with Hashimoto thyroiditis and Graves' disease in comparison with non-autoimmune thyroid disease patients and did not differ between autoimmune patients with or without thyroid peroxidase antibodies. The latter correlated positively with age. Conclusions: Our findings suggest that Se supplementation might have a beneficial effect in autoimmune thyroid patients.

Original languageEnglish
Pages (from-to)685-692
JournalExpert Review of Endocrinology and Metabolism
Issue number6
Publication statusPublished - 1 Nov 2014
Externally publishedYes


  • Graves' disease
  • Hashimoto's thyroiditis
  • non-autoimmune thyroid disease
  • plasma selenium
  • plasma selenoprotein P
  • selenium status
  • thyroid diseases
  • urine iodine

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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