Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries

Gerasimos E. Krassas; Nikolaos Pontikides; Kostas Tziomalos; Themistoklis Tzotzas; Ioana Zosin; Mihaela Vlad; Anton Luger; Alois Gessl; Rodrig Marculescu; Vincenzo Toscano; Sara Morgante; Enrico Papini; Valdis Pirags; Ilze Konrade; Sandra Hybsier; Peter J. Hofmann; Lutz Schomburg; Josef Köhrle

doi:10.1586/17446651.2014.960845

Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries

Gerasimos E. Krassas
, Nikolaos Pontikides
, Kostas Tziomalos
, Themistoklis Tzotzas
, Ioana Zosin
, Mihaela Vlad
, Anton Luger
, Alois Gessl
, Rodrig Marculescu
, Vincenzo Toscano
, Sara Morgante
, Enrico Papini
, Valdis Pirags
, Ilze Konrade
, Sandra Hybsier
, Peter J. Hofmann
, Lutz Schomburg
, Josef Köhrle

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Context: Selenium supplementation has been suggested for Hashimoto thyroiditis and Graves' ophthalmopathy. Objective, Design: Our aim is to measure selenium status (p-Se, p-SePP), urine iodine (UI) levels and urine iodine/creatinine ratio (UI/C) in different thyroid diseases (n = 416) from four European countries and to compare the results between patients with and without thyroid autoimmunity. Results: p-Se and p-SePP showed positive correlation and did not correlate with UI/C. Also, these measurements were higher in patients from Italy in comparison with the other countries. Austria had the lowest UI/C ratios. Selenium deficiency exists in these four European countries. Selenium status was lower in patients with Hashimoto thyroiditis and Graves' disease in comparison with non-autoimmune thyroid disease patients and did not differ between autoimmune patients with or without thyroid peroxidase antibodies. The latter correlated positively with age. Conclusions: Our findings suggest that Se supplementation might have a beneficial effect in autoimmune thyroid patients.

Original language	English
Pages (from-to)	685-692
Journal	Expert Review of Endocrinology and Metabolism
Volume	9
Issue number	6
DOIs	https://doi.org/10.1586/17446651.2014.960845
Publication status	Published - 1 Nov 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords*

Graves' disease
Hashimoto's thyroiditis
non-autoimmune thyroid disease
plasma selenium
plasma selenoprotein P
selenium status
thyroid diseases
urine iodine

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1586/17446651.2014.960845

Cite this

Krassas, G. E., Pontikides, N., Tziomalos, K., Tzotzas, T., Zosin, I., Vlad, M., Luger, A., Gessl, A., Marculescu, R., Toscano, V., Morgante, S., Papini, E., Pirags, V., Konrade, I., Hybsier, S., Hofmann, P. J., Schomburg, L., & Köhrle, J. (2014). Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries. Expert Review of Endocrinology and Metabolism, 9(6), 685-692. https://doi.org/10.1586/17446651.2014.960845

@article{d61d34c5efdb4658a76ba37cdd27f055,

title = "Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries",

abstract = "Context: Selenium supplementation has been suggested for Hashimoto thyroiditis and Graves' ophthalmopathy. Objective, Design: Our aim is to measure selenium status (p-Se, p-SePP), urine iodine (UI) levels and urine iodine/creatinine ratio (UI/C) in different thyroid diseases (n = 416) from four European countries and to compare the results between patients with and without thyroid autoimmunity. Results: p-Se and p-SePP showed positive correlation and did not correlate with UI/C. Also, these measurements were higher in patients from Italy in comparison with the other countries. Austria had the lowest UI/C ratios. Selenium deficiency exists in these four European countries. Selenium status was lower in patients with Hashimoto thyroiditis and Graves' disease in comparison with non-autoimmune thyroid disease patients and did not differ between autoimmune patients with or without thyroid peroxidase antibodies. The latter correlated positively with age. Conclusions: Our findings suggest that Se supplementation might have a beneficial effect in autoimmune thyroid patients.",

keywords = "Graves' disease, Hashimoto's thyroiditis, non-autoimmune thyroid disease, plasma selenium, plasma selenoprotein P, selenium status, thyroid diseases, urine iodine",

author = "Krassas, \{Gerasimos E.\} and Nikolaos Pontikides and Kostas Tziomalos and Themistoklis Tzotzas and Ioana Zosin and Mihaela Vlad and Anton Luger and Alois Gessl and Rodrig Marculescu and Vincenzo Toscano and Sara Morgante and Enrico Papini and Valdis Pirags and Ilze Konrade and Sandra Hybsier and Hofmann, \{Peter J.\} and Lutz Schomburg and Josef K{\"o}hrle",

note = "Funding Information: This work was supported partially from U.E.M.S, section of Endocrinology and Metabolism (to GE Krassas) by Deutsche Forschungsgemeinschaft (DFG; SCHO849/4-1) and the German Federal Ministry of Economics and Technology (BMWi; KF2263202CS2) (to L Schomburg). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: {\textcopyright} Informa UK, Ltd.",

year = "2014",

month = nov,

day = "1",

doi = "10.1586/17446651.2014.960845",

language = "English",

volume = "9",

pages = "685--692",

journal = "Expert Review of Endocrinology and Metabolism",

issn = "1744-6651",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

Krassas, GE, Pontikides, N, Tziomalos, K, Tzotzas, T, Zosin, I, Vlad, M, Luger, A, Gessl, A, Marculescu, R, Toscano, V, Morgante, S, Papini, E, Pirags, V, Konrade, I, Hybsier, S, Hofmann, PJ, Schomburg, L & Köhrle, J 2014, 'Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries', Expert Review of Endocrinology and Metabolism, vol. 9, no. 6, pp. 685-692. https://doi.org/10.1586/17446651.2014.960845

TY - JOUR

T1 - Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries

AU - Krassas, Gerasimos E.

AU - Pontikides, Nikolaos

AU - Tziomalos, Kostas

AU - Tzotzas, Themistoklis

AU - Zosin, Ioana

AU - Vlad, Mihaela

AU - Luger, Anton

AU - Gessl, Alois

AU - Marculescu, Rodrig

AU - Toscano, Vincenzo

AU - Morgante, Sara

AU - Papini, Enrico

AU - Pirags, Valdis

AU - Konrade, Ilze

AU - Hybsier, Sandra

AU - Hofmann, Peter J.

AU - Schomburg, Lutz

AU - Köhrle, Josef

N1 - Funding Information: This work was supported partially from U.E.M.S, section of Endocrinology and Metabolism (to GE Krassas) by Deutsche Forschungsgemeinschaft (DFG; SCHO849/4-1) and the German Federal Ministry of Economics and Technology (BMWi; KF2263202CS2) (to L Schomburg). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: © Informa UK, Ltd.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Context: Selenium supplementation has been suggested for Hashimoto thyroiditis and Graves' ophthalmopathy. Objective, Design: Our aim is to measure selenium status (p-Se, p-SePP), urine iodine (UI) levels and urine iodine/creatinine ratio (UI/C) in different thyroid diseases (n = 416) from four European countries and to compare the results between patients with and without thyroid autoimmunity. Results: p-Se and p-SePP showed positive correlation and did not correlate with UI/C. Also, these measurements were higher in patients from Italy in comparison with the other countries. Austria had the lowest UI/C ratios. Selenium deficiency exists in these four European countries. Selenium status was lower in patients with Hashimoto thyroiditis and Graves' disease in comparison with non-autoimmune thyroid disease patients and did not differ between autoimmune patients with or without thyroid peroxidase antibodies. The latter correlated positively with age. Conclusions: Our findings suggest that Se supplementation might have a beneficial effect in autoimmune thyroid patients.

AB - Context: Selenium supplementation has been suggested for Hashimoto thyroiditis and Graves' ophthalmopathy. Objective, Design: Our aim is to measure selenium status (p-Se, p-SePP), urine iodine (UI) levels and urine iodine/creatinine ratio (UI/C) in different thyroid diseases (n = 416) from four European countries and to compare the results between patients with and without thyroid autoimmunity. Results: p-Se and p-SePP showed positive correlation and did not correlate with UI/C. Also, these measurements were higher in patients from Italy in comparison with the other countries. Austria had the lowest UI/C ratios. Selenium deficiency exists in these four European countries. Selenium status was lower in patients with Hashimoto thyroiditis and Graves' disease in comparison with non-autoimmune thyroid disease patients and did not differ between autoimmune patients with or without thyroid peroxidase antibodies. The latter correlated positively with age. Conclusions: Our findings suggest that Se supplementation might have a beneficial effect in autoimmune thyroid patients.

KW - Graves' disease

KW - Hashimoto's thyroiditis

KW - non-autoimmune thyroid disease

KW - plasma selenium

KW - plasma selenoprotein P

KW - selenium status

KW - thyroid diseases

KW - urine iodine

UR - https://www.scopus.com/pages/publications/84911471336

U2 - 10.1586/17446651.2014.960845

DO - 10.1586/17446651.2014.960845

M3 - Article

AN - SCOPUS:84911471336

SN - 1744-6651

VL - 9

SP - 685

EP - 692

JO - Expert Review of Endocrinology and Metabolism

JF - Expert Review of Endocrinology and Metabolism

IS - 6

ER -

Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries

Abstract

UN SDGs

Keywords*

Field of Science*

Publication Type*

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