Serum procalcitonin is a sensitive marker for septic shock and mortality in secondary peritonitis

Guntars Pupelis, Nadezda Drozdova, Maksims Mukans, Manu Lng Malbrain

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Background: Serum procalcitonin (PCT) is considered to be a sensitive marker for the early recognition of sever infection. The aim of this study was to review the diagnostic accuracy of serum procalcitonin levels to predict the ris of septic shock and mortality in patients with secondary peritonitis Methods: We carried out a retrospective review of patients (November 2010 to November 2012) admitted to th surgical intensive care unit (ICU) with secondary peritonitis classified into localised peritonitis (LP) or diffuse peritoniti (DP) groups. Organ dysfunction was assessed with the SOFA score. Demographic data was collected as well as result for neutrophil count, C-reactive protein, blood lactate, and PCT levels. The primary end-point was ICU mortality Results: From a total of 222 patients, 123 were allocated to the LP group and 99 to the DP group. Severe sepsis wa observed in 41.9% of all patients in the DP group. The PCT levels increased significantly in the DP group, with th development of septic shock in 29 patients. Higher PCT levels were associated with an increased risk for septic shoc with a cut-off value of 15.3 ng mL-1 and an increased risk for mortality with a cut-off value 19.6 ng mL-1. A total o 59.1% of those who developed septic shock died Conclusion: An increase in PCT levels is an indirect sign of diffuse secondary peritonitis and this is associated wit an increased risk of septic shock. Increased PCT level on admission is associated with an increased risk of mortalit in this category of patients.

Original languageEnglish
Pages (from-to)262-273
Number of pages12
JournalAnaesthesiology Intensive Therapy
Volume46
Issue number4
Publication statusPublished - 1 Sep 2014
Externally publishedYes

Keywords*

  • Mortality
  • Procalcitonin
  • Secondary peritonitis
  • Septic shock

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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