Significance of hypouricaemia in the development of neurodegenerative diseases

Maximiliane Trapp (Coresponding Author), Anna Mihailova, Natalija Kakurina, Modra Murovska

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Hypouricaemia has received relatively little attention in the literature. As a result, there is lessawareness or understanding of the potential risks of low uric acid levels. Emerging research indi-cates that normal uric acid levels may have an antioxidative and neuroprotective effect. Thisstudy aims to investigate possible associations between hypouricaemia and neurodegenerativedisease. Data was collected from seventy-seven outpatients and inpatients who underwent rou-tine uric acid testing, who were then stratified into patients with and without neurodegenerativedisease. Patients with renal pathologies and patients using uric acid altering medications were ex-cluded from the study. There was a significant difference in the prevalence of Alzheimer’s diseasebetween hypouricemic and normouricemic patients (p= 0.001), however there was no differencein the prevalence of vascular dementia (p= 0.45). This study provides evidence that hypouricae-mia has potential effects on health, specifically on the rate of neurodegenerative diseases suchas Alzheimer’s disease and gives weight to the potential neuroprotective role of uric acid.
Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalProceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences
Issue number2
Publication statusPublished - 1 Apr 2021


  • uric acid, Alzheimer’s disease, vascular dementia

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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