Silver- and/or titanium-doped β-tricalcium phosphate bioceramic with antibacterial activity against Staphylococcus aureus

Liga Stipniece; Ingus Skadins; Marika Mosina

doi:10.1016/j.ceramint.2021.12.232

Silver- and/or titanium-doped β-tricalcium phosphate bioceramic with antibacterial activity against Staphylococcus aureus

Liga Stipniece (Corresponding Author)
, Ingus Skadins
, Marika Mosina

Department of Biology and Microbiology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Ag- and/or Ti-doped apatitic-tricalcium phosphate powders were synthesized by wet chemical precipitation method. Regardless of the element composition, calcination of the Ag- and/or Ti-doped apatitic tricalcium phosphate powders at 900 °C gave phase-pure β-tricalcium phosphate. Cumulative release of Ca(II) and Ag(I) ions in TRIS-HCl buffer solution was determined. Increase of the solubility of the β-tricalcium phosphate was observed with the addition of Ti. Furthermore, prolonged (up to 28 days) release of the Ag(I) ions from the Ag-doped and the Ag- and Ti-co-doped β-tricalcium phosphate was observed. Minimum inhibitory concentration and antibacterial activity of the Ag- and/or Ti-doped β-tricalcium phosphate powders against Gram-positive Staphylococcus aureus was determined. It was observed that the addition of both, Ti and Ag, confers antibacterial properties of the β-tricalcium phosphate against Staphylococcus aureus.

Original language	English
Pages (from-to)	10195-10201
Number of pages	7
Journal	Ceramics International
Volume	48
Issue number	7
DOIs	https://doi.org/10.1016/j.ceramint.2021.12.232
Publication status	Published - 1 Apr 2022

Keywords*

Ag-/Ti-doping
Antibacterial properties
Bioceramics
β-tricalcium phosphate

Field of Science*

1.4 Chemical sciences
2.9 Industrial biotechnology

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.ceramint.2021.12.232Licence: CC BY-NC-ND

https://www.sciencedirect.com/science/article/pii/S0272884221040268

Cite this

@article{c06eeb8ca4f4493f936d7d8ef63fbc86,

title = "Silver- and/or titanium-doped β-tricalcium phosphate bioceramic with antibacterial activity against Staphylococcus aureus",

abstract = "Ag- and/or Ti-doped apatitic-tricalcium phosphate powders were synthesized by wet chemical precipitation method. Regardless of the element composition, calcination of the Ag- and/or Ti-doped apatitic tricalcium phosphate powders at 900 °C gave phase-pure β-tricalcium phosphate. Cumulative release of Ca(II) and Ag(I) ions in TRIS-HCl buffer solution was determined. Increase of the solubility of the β-tricalcium phosphate was observed with the addition of Ti. Furthermore, prolonged (up to 28 days) release of the Ag(I) ions from the Ag-doped and the Ag- and Ti-co-doped β-tricalcium phosphate was observed. Minimum inhibitory concentration and antibacterial activity of the Ag- and/or Ti-doped β-tricalcium phosphate powders against Gram-positive Staphylococcus aureus was determined. It was observed that the addition of both, Ti and Ag, confers antibacterial properties of the β-tricalcium phosphate against Staphylococcus aureus.",

keywords = "Ag-/Ti-doping, Antibacterial properties, Bioceramics, β-tricalcium phosphate",

author = "Liga Stipniece and Ingus Skadins and Marika Mosina",

note = "Funding Information: The authors acknowledge financial support from the European Union's Horizon 2020 research and innovation programme under the grant agreement No. 857287 . Funding Information: This work has been supported by the European Regional Development Fund within the Activity 1.1.1.2 ?Post-doctoral Research Aid? of the Specific Aid Objective 1.1.1 ?To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure? of the Operational Programme ?Growth and Employment? (No. 1.1.1.2/VIAA/2/18/339). The authors acknowledge financial support from the European Union's Horizon 2020 research and innovation programme under the grant agreement No. 857287. Funding Information: This work has been supported by the European Regional Development Fund within the Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment” (No. 1.1.1.2/VIAA/2/18/339). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd and Techna Group S.r.l.",

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language = "English",

volume = "48",

pages = "10195--10201",

journal = "Ceramics International",

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T1 - Silver- and/or titanium-doped β-tricalcium phosphate bioceramic with antibacterial activity against Staphylococcus aureus

AU - Stipniece, Liga

AU - Skadins, Ingus

AU - Mosina, Marika

N1 - Funding Information: The authors acknowledge financial support from the European Union's Horizon 2020 research and innovation programme under the grant agreement No. 857287 . Funding Information: This work has been supported by the European Regional Development Fund within the Activity 1.1.1.2 ?Post-doctoral Research Aid? of the Specific Aid Objective 1.1.1 ?To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure? of the Operational Programme ?Growth and Employment? (No. 1.1.1.2/VIAA/2/18/339). The authors acknowledge financial support from the European Union's Horizon 2020 research and innovation programme under the grant agreement No. 857287. Funding Information: This work has been supported by the European Regional Development Fund within the Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment” (No. 1.1.1.2/VIAA/2/18/339). Publisher Copyright: © 2021 Elsevier Ltd and Techna Group S.r.l.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Ag- and/or Ti-doped apatitic-tricalcium phosphate powders were synthesized by wet chemical precipitation method. Regardless of the element composition, calcination of the Ag- and/or Ti-doped apatitic tricalcium phosphate powders at 900 °C gave phase-pure β-tricalcium phosphate. Cumulative release of Ca(II) and Ag(I) ions in TRIS-HCl buffer solution was determined. Increase of the solubility of the β-tricalcium phosphate was observed with the addition of Ti. Furthermore, prolonged (up to 28 days) release of the Ag(I) ions from the Ag-doped and the Ag- and Ti-co-doped β-tricalcium phosphate was observed. Minimum inhibitory concentration and antibacterial activity of the Ag- and/or Ti-doped β-tricalcium phosphate powders against Gram-positive Staphylococcus aureus was determined. It was observed that the addition of both, Ti and Ag, confers antibacterial properties of the β-tricalcium phosphate against Staphylococcus aureus.

AB - Ag- and/or Ti-doped apatitic-tricalcium phosphate powders were synthesized by wet chemical precipitation method. Regardless of the element composition, calcination of the Ag- and/or Ti-doped apatitic tricalcium phosphate powders at 900 °C gave phase-pure β-tricalcium phosphate. Cumulative release of Ca(II) and Ag(I) ions in TRIS-HCl buffer solution was determined. Increase of the solubility of the β-tricalcium phosphate was observed with the addition of Ti. Furthermore, prolonged (up to 28 days) release of the Ag(I) ions from the Ag-doped and the Ag- and Ti-co-doped β-tricalcium phosphate was observed. Minimum inhibitory concentration and antibacterial activity of the Ag- and/or Ti-doped β-tricalcium phosphate powders against Gram-positive Staphylococcus aureus was determined. It was observed that the addition of both, Ti and Ag, confers antibacterial properties of the β-tricalcium phosphate against Staphylococcus aureus.

KW - Ag-/Ti-doping

KW - Antibacterial properties

KW - Bioceramics

KW - β-tricalcium phosphate

UR - https://www.scopus.com/pages/publications/85122134742

U2 - 10.1016/j.ceramint.2021.12.232

DO - 10.1016/j.ceramint.2021.12.232

M3 - Article

AN - SCOPUS:85122134742

SN - 0272-8842

VL - 48

SP - 10195

EP - 10201

JO - Ceramics International

JF - Ceramics International

IS - 7

ER -

Silver- and/or titanium-doped β-tricalcium phosphate bioceramic with antibacterial activity against Staphylococcus aureus

Abstract

Keywords*

Field of Science*

Publication Type*

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