Solution NMR structure of Borrelia burgdorferi outer surface lipoprotein BBP28, a member of the mlp protein family

Jēkabs Fridmanis, Mārtiņš Otikovs, Kalvis Brangulis, Kaspars Tārs, Kristaps Jaudzems (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Lyme disease is the most widespread vector-transmitted disease in North America and Europe, caused by infection with Borrelia burgdorferi sensu lato complex spirochetes. We report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBP28, a member of the multicopy lipoprotein (mlp) family. The structure comprises a tether peptide, five α-helices and an extended C-terminal loop. The fold is similar to that of Borrelia turicatae outer surface protein BTA121, which is known to bind lipids. These results contribute to the understanding of Lyme disease pathogenesis by revealing the molecular structure of a protein from the widely found mlp family.

Original languageEnglish
Pages (from-to)588-594
JournalProteins: Structure, Function and Bioinformatics
Volume89
Issue number5
DOIs
Publication statusPublished - May 2021

Keywords

  • BBP28
  • cp32 plasmid
  • mlp family
  • solution NMR structure
  • ϕBB-1 phage

Field of Science

  • 1.6 Biological sciences
  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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