TY - JOUR
T1 - Somatic multi-comorbidity and disability in patients with psychiatric disorders in comparison to the general population
T2 - A quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)
AU - Fountoulakis, Konstantinos N.
AU - Karakatsoulis, Gregory
AU - Abraham, Seri
AU - Adorjan, Kristina
AU - Ahmed, Helal Uddin
AU - Alarcón, Renato D.
AU - Arai, Kiyomi
AU - Auwal, Sani Salihu
AU - Berk, Michael
AU - Bjedov, Sarah
AU - Bobes, Julio
AU - Bobes-Bascaran, Teresa
AU - Bourgin-Duchesnay, Julie
AU - Bredicean, Cristina Ana
AU - Bukelskis, Laurynas
AU - Burkadze, Akaki
AU - Abud, Indira Indiana Cabrera
AU - Castilla-Puentes, Ruby
AU - Cetkovich, Marcelo
AU - Colon-Rivera, Hector
AU - Corral, Ricardo
AU - Cortez-Vergara, Carla
AU - Crepin, Piirika
AU - De Berardis, Domenico
AU - Delgado, Sergio Zamora
AU - De Lucena, David
AU - De Sousa, Avinash
AU - Stefano, Ramona Di
AU - Dodd, Seetal
AU - Elek, Livia Priyanka
AU - Elissa, Anna
AU - Erdelyi-Hamza, Berta
AU - Erzin, Gamze
AU - Etchevers, Martin J.
AU - Falkai, Peter
AU - Farcas, Adriana
AU - Fedotov, Ilya
AU - Filatova, Viktoriia
AU - Fountoulakis, Nikolaos K.
AU - Frankova, Iryna
AU - Franza, Francesco
AU - Frias, Pedro
AU - Galako, Tatiana
AU - Garay, Cristian J.
AU - Garcia-Álvarez, Leticia
AU - García-Portilla, Maria Paz
AU - Gonda, Xenia
AU - Gondek, Tomasz M.
AU - Rancans, Elmars
AU - Vrublevska, Jelena
N1 - Publisher Copyright:
© The Author(s), 2024. Published by Cambridge University Press.
PY - 2024/4/25
Y1 - 2024/4/25
N2 - Background. The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders. Methods. The sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based on the registration of previous history that could serve as a fair approximation for the lifetime prevalence of various medical conditions. Results. About 24.5% reported a history of somatic and 26.14% of mental disorders. Mental disorders were by far the most prevalent group of medical conditions. Comorbidity of any somatic with any mental disorder was reported by 8.21%. One-third to almost two-thirds of somatic patients were also suffering from a mental disorder depending on the severity and multicomorbidity. Bipolar and psychotic patients and to a lesser extent depressives, manifested an earlier (15–20 years) manifestation of somatic multicomorbidity, severe disability, and probably earlier death. The overwhelming majority of patients with mental disorders were not receiving treatment or were being treated in a way that was not recommended. Antipsychotics and antidepressants were not related to the development of metabolic syndrome. Conclusions. The finding that one-third to almost two-thirds of somatic patients also suffered from a mental disorder strongly suggests that psychiatry is the field with the most trans-specialty and interdisciplinary value and application points to the importance of teaching psychiatry and mental health in medical schools and also to the need for more technocratically oriented training of psychiatric residents.
AB - Background. The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders. Methods. The sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based on the registration of previous history that could serve as a fair approximation for the lifetime prevalence of various medical conditions. Results. About 24.5% reported a history of somatic and 26.14% of mental disorders. Mental disorders were by far the most prevalent group of medical conditions. Comorbidity of any somatic with any mental disorder was reported by 8.21%. One-third to almost two-thirds of somatic patients were also suffering from a mental disorder depending on the severity and multicomorbidity. Bipolar and psychotic patients and to a lesser extent depressives, manifested an earlier (15–20 years) manifestation of somatic multicomorbidity, severe disability, and probably earlier death. The overwhelming majority of patients with mental disorders were not receiving treatment or were being treated in a way that was not recommended. Antipsychotics and antidepressants were not related to the development of metabolic syndrome. Conclusions. The finding that one-third to almost two-thirds of somatic patients also suffered from a mental disorder strongly suggests that psychiatry is the field with the most trans-specialty and interdisciplinary value and application points to the importance of teaching psychiatry and mental health in medical schools and also to the need for more technocratically oriented training of psychiatric residents.
KW - disability
KW - epidemiology
KW - multi-comorbidity
KW - premature death
KW - somatic-mental comorbidity
UR - http://www.scopus.com/inward/record.url?scp=85184507914&partnerID=8YFLogxK
U2 - 10.1017/S1092852924000026
DO - 10.1017/S1092852924000026
M3 - Article
C2 - 38269574
AN - SCOPUS:85184507914
SN - 1092-8529
VL - 29
SP - 126
EP - 149
JO - CNS Spectrums
JF - CNS Spectrums
IS - 2
ER -
