Sorbitol as a melt binder in twin-screw melt granulation for effervescent tablets preparation

Zoltan Mark Horvath; Kirils Kukuls; Alīna Jaroslava Frolova; Marta Žogota; Elzbieta Maria Buczkowska; Līga Pētersone; Valentyn Mohylyuk

doi:10.13140/RG.2.2.19394.08642

Sorbitol as a melt binder in twin-screw melt granulation for effervescent tablets preparation

Zoltan Mark Horvath, Kirils Kukuls, Alīna Jaroslava Frolova, Marta Žogota, Elzbieta Maria Buczkowska, Līga Pētersone, Valentyn Mohylyuk (Corresponding Author)

Lead Researcher Group

Research output: Contribution to conference › Poster

1 Downloads (Pure)

Original language	English
Number of pages	1
DOIs	https://doi.org/10.13140/RG.2.2.19394.08642
Publication status	Published - Jun 2025
Event	16th Global Drug Delivery and Formulation Summit (DDF) - Friedrichstraße 151 Dorotheenstraße 65 (10117 Berlin, Germany), Berlin, Germany Duration: 2 Jun 2025 → 4 Jun 2025 Conference number: 16 https://ddfevent.com/2025/en/page/home

Conference

Conference	16th Global Drug Delivery and Formulation Summit (DDF)
Abbreviated title	DDF
Country/Territory	Germany
City	Berlin
Period	2/06/25 → 4/06/25
Internet address	https://ddfevent.com/2025/en/page/home

Keywords*

polyols
granulation
melt granulation
twin-screw melt granulation
effervescent granules
effervescent tablets
sorbitol

Field of Science*

1.4 Chemical sciences
2.5 Materials engineering
3.1 Basic medicine

Publication Type*

3.4. Other publications in conference proceedings (including local)

Access to Document

10.13140/RG.2.2.19394.08642Licence: CC BY

Sorbitol as a melt binder in twin-screw melt granulation for effervescent tablets preparationFinal published version, 666 KB

2 Article
1 Poster

Determination of polyols' intrinsic dissolution rate as an important characteristic for pre- and formulation
Buczkowska, E. M., Frolova, A. J., Kukuls, K., Horvath, Z. M., Žogota, M., Pētersone, L. & Mohylyuk, V. (Corresponding Author), Jun 2025. 1 p.
Research output: Contribution to conference › Poster

Open Access
File

1 Downloads (Pure)
Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder
Horvath, Z. M., Kukuls, K., Frolova, A. J., Žogota, M., Buczkowska, E. M., Pētersone, L. & Mohylyuk, V. (Corresponding Author), 21 May 2025, In: Pharmaceutics. 17, 5, 15 p., 676.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Downloads (Pure)
Twin-screw melt granulation with PEG 8000: Effect of binder particle size and processing temperature on the granule and tablet properties
Horváth, Z. M., Petersone, L. & Mohylyuk, V. (Corresponding Author), Sept 2024, In: Advanced Powder Technology. 35, 9, 104585.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)

1 Active

Suitability of sugar alcohols (polyols) as binders in twin-screw melt granulation for preparation of high-drug-loaded immediate-release tablets with superior mechanical properties
Mohylyuk, V. (Project leader), Buczkowska, E. M. (Leading expert), Pētersone, L. (Leading expert), Žogota, M. (Expert), Horvath, Z. M. (Participant), Kukuls, K. (Participant), Frolova, A. J. (Participant) & Paulausks, A. (Expert)
European Commission
1/04/24 → 31/03/26
Project: Consolidation grants

Cite this

@conference{3ceb69095f6440b385b6517690314476,

title = "Sorbitol as a melt binder in twin-screw melt granulation for effervescent tablets preparation",

keywords = "polyols, granulation, melt granulation, twin-screw melt granulation, effervescent granules, effervescent tablets, sorbitol",

author = "Horvath, \{Zoltan Mark\} and Kirils Kukuls and Frolova, \{Alīna Jaroslava\} and Marta {\v Z}ogota and Buczkowska, \{Elzbieta Maria\} and Līga Pētersone and Valentyn Mohylyuk",

year = "2025",

month = jun,

doi = "10.13140/RG.2.2.19394.08642",

language = "English",

note = "16th Global Drug Delivery and Formulation Summit (DDF), DDF ; Conference date: 02-06-2025 Through 04-06-2025",

url = "https://ddfevent.com/2025/en/page/home",

}

TY - CONF

T1 - Sorbitol as a melt binder in twin-screw melt granulation for effervescent tablets preparation

AU - Horvath, Zoltan Mark

AU - Kukuls, Kirils

AU - Frolova, Alīna Jaroslava

AU - Žogota, Marta

AU - Buczkowska, Elzbieta Maria

AU - Pētersone, Līga

AU - Mohylyuk, Valentyn

N1 - Conference code: 16

PY - 2025/6

Y1 - 2025/6

KW - polyols

KW - granulation

KW - melt granulation

KW - twin-screw melt granulation

KW - effervescent granules

KW - effervescent tablets

KW - sorbitol

U2 - 10.13140/RG.2.2.19394.08642

DO - 10.13140/RG.2.2.19394.08642

M3 - Poster

T2 - 16th Global Drug Delivery and Formulation Summit (DDF)

Y2 - 2 June 2025 through 4 June 2025

ER -

Sorbitol as a melt binder in twin-screw melt granulation for effervescent tablets preparation

Conference

Keywords*

Field of Science*

Publication Type*

Access to Document

Research output

Determination of polyols' intrinsic dissolution rate as an important characteristic for pre- and formulation

Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder

Twin-screw melt granulation with PEG 8000: Effect of binder particle size and processing temperature on the granule and tablet properties

Projects

Suitability of sugar alcohols (polyols) as binders in twin-screw melt granulation for preparation of high-drug-loaded immediate-release tablets with superior mechanical properties

Cite this