Sperm chromatin structure and male fertility: biological and clinical aspects

Juris Erenpreiss; M. Spano; J. Erenpreisa; M. Bungum; A. Giwercman

doi:10.1111/j.1745-7262.2006.00112.x

Sperm chromatin structure and male fertility: biological and clinical aspects

Juris Erenpreiss, M. Spano, J. Erenpreisa, M. Bungum, A. Giwercman

Research output: Contribution to journal › Review article › peer-review

243 Citations (Scopus)

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Abstract

Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.

Original language	English
Pages (from-to)	11-29
Number of pages	19
Journal	Asian Journal of Andrology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1111/j.1745-7262.2006.00112.x
Publication status	Published - Jan 2006
Externally published	Yes

Keywords*

Damage
DNA
Human
Infertility
Sperm

Field of Science*

3.1 Basic medicine
3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1745-7262.2006.00112.x

Sperm chromatin structure and male fertility

Cite this

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title = "Sperm chromatin structure and male fertility: biological and clinical aspects",

abstract = "Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.",

keywords = "Damage, DNA, Human, Infertility, Sperm",

author = "Juris Erenpreiss and M. Spano and J. Erenpreisa and M. Bungum and A. Giwercman",

year = "2006",

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doi = "10.1111/j.1745-7262.2006.00112.x",

language = "English",

volume = "8",

pages = "11--29",

journal = "Asian Journal of Andrology",

issn = "1008-682X",

publisher = "Wolters Kluwer Medknow Publications",

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TY - JOUR

T1 - Sperm chromatin structure and male fertility

T2 - biological and clinical aspects

AU - Erenpreiss, Juris

AU - Spano, M.

AU - Erenpreisa, J.

AU - Bungum, M.

AU - Giwercman, A.

PY - 2006/1

Y1 - 2006/1

N2 - Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.

AB - Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.

KW - Damage

KW - DNA

KW - Human

KW - Infertility

KW - Sperm

UR - http://www.scopus.com/inward/record.url?scp=30444457711&partnerID=8YFLogxK

U2 - 10.1111/j.1745-7262.2006.00112.x

DO - 10.1111/j.1745-7262.2006.00112.x

M3 - Review article

C2 - 16372115

AN - SCOPUS:30444457711

SN - 1008-682X

VL - 8

SP - 11

EP - 29

JO - Asian Journal of Andrology

JF - Asian Journal of Andrology

IS - 1

ER -

Sperm chromatin structure and male fertility: biological and clinical aspects

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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