Sperm chromatin structure and male fertility: biological and clinical aspects

Juris Erenpreiss, M. Spano, J. Erenpreisa, M. Bungum, A. Giwercman

Research output: Contribution to journalReview articlepeer-review

220 Citations (Scopus)

Abstract

Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.

Original languageEnglish
Pages (from-to)11-29
Number of pages19
JournalAsian Journal of Andrology
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2006
Externally publishedYes

Keywords*

  • Damage
  • DNA
  • Human
  • Infertility
  • Sperm

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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