Squamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas

Agita Jukna; Gloria Montanari; Maria Cecilia Mengoli; Alberto Cavazza; Marisa Covi; Fausto Barbieri; Federica Bertolini; Giulio Rossi

doi:10.1016/j.jtho.2015.12.096

Squamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas

Agita Jukna, Gloria Montanari, Maria Cecilia Mengoli, Alberto Cavazza, Marisa Covi, Fausto Barbieri, Federica Bertolini, Giulio Rossi

Department of Pathology

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45 Citations (Scopus)

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Abstract

The authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) "transformation" concurrently with T790M EGFR mutation, leading to acquired resistance to EGFR inhibitors. Moreover, the histologic change of EGFR-mutant lung adenocarcinoma into SCC has been recently reported in literature. The histological transformation to SCC appears as a novel mechanism of acquired EGFR TKI resistance in EGFR-mutated adenocarcinomas and it may be challenging for treatment.

Original language	English
Pages (from-to)	e49-e51
Number of pages	3
Journal	Journal of Thoracic Oncology
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/j.jtho.2015.12.096
Publication status	Published - 2016

Keywords*

Adenocarcinoma
EGFR
Lung
Squamous cell carcinoma
T790M

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.jtho.2015.12.096

Squamous Cell Carcinoma TransformationFinal published version, 679 KB

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title = "Squamous cell carcinoma {"}transformation{"} concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas",

abstract = "The authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) {"}transformation{"} concurrently with T790M EGFR mutation, leading to acquired resistance to EGFR inhibitors. Moreover, the histologic change of EGFR-mutant lung adenocarcinoma into SCC has been recently reported in literature. The histological transformation to SCC appears as a novel mechanism of acquired EGFR TKI resistance in EGFR-mutated adenocarcinomas and it may be challenging for treatment.",

keywords = "Adenocarcinoma, EGFR, Lung, Squamous cell carcinoma, T790M",

author = "Agita Jukna and Gloria Montanari and Mengoli, {Maria Cecilia} and Alberto Cavazza and Marisa Covi and Fausto Barbieri and Federica Bertolini and Giulio Rossi",

note = "Publisher Copyright: {\textcopyright} 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc.",

year = "2016",

doi = "10.1016/j.jtho.2015.12.096",

language = "English",

volume = "11",

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T1 - Squamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas

AU - Jukna, Agita

AU - Montanari, Gloria

AU - Mengoli, Maria Cecilia

AU - Cavazza, Alberto

AU - Covi, Marisa

AU - Barbieri, Fausto

AU - Bertolini, Federica

AU - Rossi, Giulio

PY - 2016

Y1 - 2016

N2 - The authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) "transformation" concurrently with T790M EGFR mutation, leading to acquired resistance to EGFR inhibitors. Moreover, the histologic change of EGFR-mutant lung adenocarcinoma into SCC has been recently reported in literature. The histological transformation to SCC appears as a novel mechanism of acquired EGFR TKI resistance in EGFR-mutated adenocarcinomas and it may be challenging for treatment.

AB - The authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) "transformation" concurrently with T790M EGFR mutation, leading to acquired resistance to EGFR inhibitors. Moreover, the histologic change of EGFR-mutant lung adenocarcinoma into SCC has been recently reported in literature. The histological transformation to SCC appears as a novel mechanism of acquired EGFR TKI resistance in EGFR-mutated adenocarcinomas and it may be challenging for treatment.

KW - Adenocarcinoma

KW - EGFR

KW - Lung

KW - Squamous cell carcinoma

KW - T790M

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M3 - Article

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AN - SCOPUS:84962815723

SN - 1556-0864

VL - 11

SP - e49-e51

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

IS - 4

ER -

Squamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas

Abstract

Keywords*

Field of Science*

Publication Type*

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