TY - JOUR
T1 - Staphylococcus aureus bloodstream infections
T2 - Diverging trends of meticillin-resistant and meticillin-susceptible isolates, EU/EEA, 2005 to 2018
AU - Gagliotti, Carlo
AU - Högberg, Liselotte Diaz
AU - Billström, Hanna
AU - Eckmanns, Tim
AU - Giske, Christian G.
AU - Heuer, Ole E.
AU - Jarlier, Vincent
AU - Kahlmeter, Gunnar
AU - Wong, Danilo Lo Fo
AU - Monen, Jos
AU - Murchan, Stephen
AU - Simonsen, Gunnar Skov
AU - Šubelj, Maja
AU - Andrašević, Arjana Tambić
AU - Żabicka, Dorota
AU - Žemličková, Helena
AU - Monnet, Dominique L.
AU - EARS-Net study group participants
A2 - Strauss, Reinhild
A2 - Catteau, Lucy
A2 - Marteva-Proevska, Yuliya Stoyanova
A2 - Soprek, Silvija
A2 - Maikanti-Charalampous, Panagiota
A2 - Jakubů, Vladislav
A2 - Petersen, Andreas
A2 - Ivanova, Marina
A2 - Lindholm, Laura
A2 - Maugat, Sylvie
A2 - Noll, Ines
A2 - Polemis, Michalis
A2 - Végh, Zsolt
A2 - Kristinsson, Karl Gústaf
A2 - Burns, Karen
A2 - Monaco, Monica
A2 - Rutkovska, Ieva
A2 - Miciulevicienė, Jolanta
A2 - Perrin, Monique
A2 - Scicluna, Elizabeth A.
A2 - Woudt, Sjoukje H.S.
A2 - Gran, Frode Width
A2 - Hryniewicz, Waleria
A2 - Caniça, Manuela
A2 - Popescu, Gabriel Adrian
A2 - Niks, Milan
A2 - Ribič, Helena
A2 - García, Maria Belén Aracil
A2 - Mäkitalo, Barbro
A2 - Hope, Russell
N1 - List of national organisations participating in EARS-Net:
https://www.ecdc.europa.eu/en/about-us/networks/disease-networks-and-laboratory-networks/ears-net-data
Funding Information:
Data from EARS-Net showed a statistically significant increase in the number of S. aureus BSI in the EU/EEA between 2005 and 2018. This trend is supported by
Publisher Copyright:
© 2021 European Centre for Disease Prevention and Control (ECDC). All rights reserved.
PY - 2021/11/18
Y1 - 2021/11/18
N2 - Background: Invasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods. Aim: The study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA). Methods: Annual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillance Network (EARS-Net). Trends of BSI were assessed at the EU/EEA level by adjusting for blood culture set rate (number of blood culture sets per 1,000 days of hospitalisation) and stratification by patient characteristics.Results: Considering a fixed cohort of laboratories consistently reporting data over the entire study period, MRSA percentages among S. aureus BSI decreased from 30.2% in 2005 to 16.3% in 2018. Concurrently, the total number of BSI caused by S. aureus increased by 57%, MSSA BSI increased by 84% and MRSA BSI decreased by 31%. All these trends were statistically significant (p<0.001). Conclusions: The results indicate an increasing health burden of MSSA BSI in the EU/EEA despite a significant decrease in the MRSA percentage. These findings highlight the importance of monitoring antimicrobial resistance trends by assessing not only resistance percentages but also the incidence of infections. Further research is needed on the factors associated with the observed trends and on their attributable risk.
AB - Background: Invasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods. Aim: The study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA). Methods: Annual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillance Network (EARS-Net). Trends of BSI were assessed at the EU/EEA level by adjusting for blood culture set rate (number of blood culture sets per 1,000 days of hospitalisation) and stratification by patient characteristics.Results: Considering a fixed cohort of laboratories consistently reporting data over the entire study period, MRSA percentages among S. aureus BSI decreased from 30.2% in 2005 to 16.3% in 2018. Concurrently, the total number of BSI caused by S. aureus increased by 57%, MSSA BSI increased by 84% and MRSA BSI decreased by 31%. All these trends were statistically significant (p<0.001). Conclusions: The results indicate an increasing health burden of MSSA BSI in the EU/EEA despite a significant decrease in the MRSA percentage. These findings highlight the importance of monitoring antimicrobial resistance trends by assessing not only resistance percentages but also the incidence of infections. Further research is needed on the factors associated with the observed trends and on their attributable risk.
UR - http://www.scopus.com/inward/record.url?scp=85121231527&partnerID=8YFLogxK
U2 - 10.2807/1560-7917.ES.2021.26.46.2002094
DO - 10.2807/1560-7917.ES.2021.26.46.2002094
M3 - Article
C2 - 34794536
AN - SCOPUS:85121231527
SN - 1025-496X
VL - 26
JO - EUROSURVEILLANCE
JF - EUROSURVEILLANCE
IS - 46
M1 - 2002094
ER -
