Strontium and strontium ranelate: Historical review of some of their functions

M. Pilmane, K. Salma-Ancane, D. Loca, J. Locs, L. Berzina-Cimdina

Research output: Contribution to journalReview articlepeer-review

154 Citations (Scopus)


The review covers historical and last decade's scientific literature on the biological and clinical role of strontium (Sr) and strontium ranelate (Sr RAN). It enrols the description of the main effects of Sr on supportive tissue, its proven and possible morphopathogenetical mechanisms and the interaction with the bone, and especially focuses on the Sr ability to inhibit osteoclasts and affect the programmed cell death. The main experimental and clinical experience regarding the Sr RAN influence in the treatment of osteoporosis and the search for correct doses is also highlighted. The review gives insight into the role of Sr/Sr RAN on stem cells, apoptosis, animal and clinical research.

Original languageEnglish
Pages (from-to)1222-1230
Number of pages9
JournalMaterials Science and Engineering C
Publication statusPublished - 1 Sept 2017


  • Bone
  • Medicine
  • Physiology
  • Strontium
  • Strontium ranelate

Field of Science*

  • 3.1 Basic medicine
  • 2.5 Materials engineering
  • 2.3 Mechanical engineering
  • 1.3 Physical sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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