Strontium and strontium ranelate: Historical review of some of their functions

M. Pilmane; K. Salma-Ancane; D. Loca; J. Locs; L. Berzina-Cimdina

doi:10.1016/j.msec.2017.05.042

Strontium and strontium ranelate: Historical review of some of their functions

M. Pilmane, K. Salma-Ancane, D. Loca, J. Locs, L. Berzina-Cimdina

Institute of Anatomy and Anthropology

Research output: Contribution to journal › Review article › peer-review

154 Citations (Scopus)

Abstract

The review covers historical and last decade's scientific literature on the biological and clinical role of strontium (Sr) and strontium ranelate (Sr RAN). It enrols the description of the main effects of Sr on supportive tissue, its proven and possible morphopathogenetical mechanisms and the interaction with the bone, and especially focuses on the Sr ability to inhibit osteoclasts and affect the programmed cell death. The main experimental and clinical experience regarding the Sr RAN influence in the treatment of osteoporosis and the search for correct doses is also highlighted. The review gives insight into the role of Sr/Sr RAN on stem cells, apoptosis, animal and clinical research.

Original language	English
Pages (from-to)	1222-1230
Number of pages	9
Journal	Materials Science and Engineering C
Volume	78
DOIs	https://doi.org/10.1016/j.msec.2017.05.042
Publication status	Published - 1 Sept 2017

Keywords*

Bone
Medicine
Physiology
Strontium
Strontium ranelate

Field of Science*

3.1 Basic medicine
2.5 Materials engineering
2.3 Mechanical engineering
1.3 Physical sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.msec.2017.05.042Licence: CC BY-NC-ND

Cite this

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title = "Strontium and strontium ranelate: Historical review of some of their functions",

abstract = "The review covers historical and last decade's scientific literature on the biological and clinical role of strontium (Sr) and strontium ranelate (Sr RAN). It enrols the description of the main effects of Sr on supportive tissue, its proven and possible morphopathogenetical mechanisms and the interaction with the bone, and especially focuses on the Sr ability to inhibit osteoclasts and affect the programmed cell death. The main experimental and clinical experience regarding the Sr RAN influence in the treatment of osteoporosis and the search for correct doses is also highlighted. The review gives insight into the role of Sr/Sr RAN on stem cells, apoptosis, animal and clinical research.",

keywords = "Bone, Medicine, Physiology, Strontium, Strontium ranelate",

author = "M. Pilmane and K. Salma-Ancane and D. Loca and J. Locs and L. Berzina-Cimdina",

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doi = "10.1016/j.msec.2017.05.042",

language = "English",

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journal = "Materials Science and Engineering C",

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TY - JOUR

T1 - Strontium and strontium ranelate

T2 - Historical review of some of their functions

AU - Pilmane, M.

AU - Salma-Ancane, K.

AU - Loca, D.

AU - Locs, J.

AU - Berzina-Cimdina, L.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - The review covers historical and last decade's scientific literature on the biological and clinical role of strontium (Sr) and strontium ranelate (Sr RAN). It enrols the description of the main effects of Sr on supportive tissue, its proven and possible morphopathogenetical mechanisms and the interaction with the bone, and especially focuses on the Sr ability to inhibit osteoclasts and affect the programmed cell death. The main experimental and clinical experience regarding the Sr RAN influence in the treatment of osteoporosis and the search for correct doses is also highlighted. The review gives insight into the role of Sr/Sr RAN on stem cells, apoptosis, animal and clinical research.

AB - The review covers historical and last decade's scientific literature on the biological and clinical role of strontium (Sr) and strontium ranelate (Sr RAN). It enrols the description of the main effects of Sr on supportive tissue, its proven and possible morphopathogenetical mechanisms and the interaction with the bone, and especially focuses on the Sr ability to inhibit osteoclasts and affect the programmed cell death. The main experimental and clinical experience regarding the Sr RAN influence in the treatment of osteoporosis and the search for correct doses is also highlighted. The review gives insight into the role of Sr/Sr RAN on stem cells, apoptosis, animal and clinical research.

KW - Bone

KW - Medicine

KW - Physiology

KW - Strontium

KW - Strontium ranelate

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U2 - 10.1016/j.msec.2017.05.042

DO - 10.1016/j.msec.2017.05.042

M3 - Review article

C2 - 28575961

AN - SCOPUS:85019871056

SN - 0928-4931

VL - 78

SP - 1222

EP - 1230

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

ER -

Strontium and strontium ranelate: Historical review of some of their functions

Abstract

Keywords*

Field of Science*

Publication Type*

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