Structural and functional analysis of bba03, borrelia burgdorferi competitive advantage promoting outer surface lipoprotein

Jēkabs Fridmanis, Raitis Bobrovs, Kalvis Brangulis, Kaspars Tārs, Kristaps Jaudzems (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

Abstract

BBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia genome, linear plasmid 54 (lp54). Although many of its genes have been identified as contributing or essential for spirochete fitness in vivo, the majority of the proteins encoded on this plasmid have no known function and lack homologs in other organisms. In this paper, we report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBA03, which is known to provide a competitive advantage to the bacteria during the transmission from tick vector to mammalian host. BBA03 shows structural homology to other outer surface lipoproteins reflecting their genetic and evolutionary relatedness. Analysis of the structure reveals a pore in BBA03, which could potentially bind lipids.

Original languageEnglish
Article number826
Pages (from-to)1-13
Number of pages13
JournalPathogens
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2020

Keywords

  • BBA03
  • Competitive advantage
  • Lp54
  • Pfam54
  • Solution NMR structure

Field of Science

  • 3.1 Basic medicine
  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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